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Shiga Toxin-Producing E. coli Infections Associated with Flour.
Crowe, Samuel J; Bottichio, Lyndsay; Shade, Lauren N; Whitney, Brooke M; Corral, Nereida; Melius, Beth; Arends, Katherine D; Donovan, Danielle; Stone, Jolianne; Allen, Krisandra; Rosner, Jessica; Beal, Jennifer; Whitlock, Laura; Blackstock, Anna; Wetherington, June; Newberry, Lisa A; Schroeder, Morgan N; Wagner, Darlene; Trees, Eija; Viazis, Stelios; Wise, Matthew E; Neil, Karen P.
Afiliação
  • Crowe SJ; From the Centers for Disease Control and Prevention (S.J.C., L.B., L.W., A.B., M.N.S., D.W., E.T., M.E.W., K.P.N.), and IHRC (L.B., D.W.), Atlanta; Food and Drug Administration, College Park, MD (L.N.S., B.M.W., J.B., S.V.); Colorado Department of Public Health and Environment, Denver (N.C.); Washin
  • Bottichio L; From the Centers for Disease Control and Prevention (S.J.C., L.B., L.W., A.B., M.N.S., D.W., E.T., M.E.W., K.P.N.), and IHRC (L.B., D.W.), Atlanta; Food and Drug Administration, College Park, MD (L.N.S., B.M.W., J.B., S.V.); Colorado Department of Public Health and Environment, Denver (N.C.); Washin
  • Shade LN; From the Centers for Disease Control and Prevention (S.J.C., L.B., L.W., A.B., M.N.S., D.W., E.T., M.E.W., K.P.N.), and IHRC (L.B., D.W.), Atlanta; Food and Drug Administration, College Park, MD (L.N.S., B.M.W., J.B., S.V.); Colorado Department of Public Health and Environment, Denver (N.C.); Washin
  • Whitney BM; From the Centers for Disease Control and Prevention (S.J.C., L.B., L.W., A.B., M.N.S., D.W., E.T., M.E.W., K.P.N.), and IHRC (L.B., D.W.), Atlanta; Food and Drug Administration, College Park, MD (L.N.S., B.M.W., J.B., S.V.); Colorado Department of Public Health and Environment, Denver (N.C.); Washin
  • Corral N; From the Centers for Disease Control and Prevention (S.J.C., L.B., L.W., A.B., M.N.S., D.W., E.T., M.E.W., K.P.N.), and IHRC (L.B., D.W.), Atlanta; Food and Drug Administration, College Park, MD (L.N.S., B.M.W., J.B., S.V.); Colorado Department of Public Health and Environment, Denver (N.C.); Washin
  • Melius B; From the Centers for Disease Control and Prevention (S.J.C., L.B., L.W., A.B., M.N.S., D.W., E.T., M.E.W., K.P.N.), and IHRC (L.B., D.W.), Atlanta; Food and Drug Administration, College Park, MD (L.N.S., B.M.W., J.B., S.V.); Colorado Department of Public Health and Environment, Denver (N.C.); Washin
  • Arends KD; From the Centers for Disease Control and Prevention (S.J.C., L.B., L.W., A.B., M.N.S., D.W., E.T., M.E.W., K.P.N.), and IHRC (L.B., D.W.), Atlanta; Food and Drug Administration, College Park, MD (L.N.S., B.M.W., J.B., S.V.); Colorado Department of Public Health and Environment, Denver (N.C.); Washin
  • Donovan D; From the Centers for Disease Control and Prevention (S.J.C., L.B., L.W., A.B., M.N.S., D.W., E.T., M.E.W., K.P.N.), and IHRC (L.B., D.W.), Atlanta; Food and Drug Administration, College Park, MD (L.N.S., B.M.W., J.B., S.V.); Colorado Department of Public Health and Environment, Denver (N.C.); Washin
  • Stone J; From the Centers for Disease Control and Prevention (S.J.C., L.B., L.W., A.B., M.N.S., D.W., E.T., M.E.W., K.P.N.), and IHRC (L.B., D.W.), Atlanta; Food and Drug Administration, College Park, MD (L.N.S., B.M.W., J.B., S.V.); Colorado Department of Public Health and Environment, Denver (N.C.); Washin
  • Allen K; From the Centers for Disease Control and Prevention (S.J.C., L.B., L.W., A.B., M.N.S., D.W., E.T., M.E.W., K.P.N.), and IHRC (L.B., D.W.), Atlanta; Food and Drug Administration, College Park, MD (L.N.S., B.M.W., J.B., S.V.); Colorado Department of Public Health and Environment, Denver (N.C.); Washin
  • Rosner J; From the Centers for Disease Control and Prevention (S.J.C., L.B., L.W., A.B., M.N.S., D.W., E.T., M.E.W., K.P.N.), and IHRC (L.B., D.W.), Atlanta; Food and Drug Administration, College Park, MD (L.N.S., B.M.W., J.B., S.V.); Colorado Department of Public Health and Environment, Denver (N.C.); Washin
  • Beal J; From the Centers for Disease Control and Prevention (S.J.C., L.B., L.W., A.B., M.N.S., D.W., E.T., M.E.W., K.P.N.), and IHRC (L.B., D.W.), Atlanta; Food and Drug Administration, College Park, MD (L.N.S., B.M.W., J.B., S.V.); Colorado Department of Public Health and Environment, Denver (N.C.); Washin
  • Whitlock L; From the Centers for Disease Control and Prevention (S.J.C., L.B., L.W., A.B., M.N.S., D.W., E.T., M.E.W., K.P.N.), and IHRC (L.B., D.W.), Atlanta; Food and Drug Administration, College Park, MD (L.N.S., B.M.W., J.B., S.V.); Colorado Department of Public Health and Environment, Denver (N.C.); Washin
  • Blackstock A; From the Centers for Disease Control and Prevention (S.J.C., L.B., L.W., A.B., M.N.S., D.W., E.T., M.E.W., K.P.N.), and IHRC (L.B., D.W.), Atlanta; Food and Drug Administration, College Park, MD (L.N.S., B.M.W., J.B., S.V.); Colorado Department of Public Health and Environment, Denver (N.C.); Washin
  • Wetherington J; From the Centers for Disease Control and Prevention (S.J.C., L.B., L.W., A.B., M.N.S., D.W., E.T., M.E.W., K.P.N.), and IHRC (L.B., D.W.), Atlanta; Food and Drug Administration, College Park, MD (L.N.S., B.M.W., J.B., S.V.); Colorado Department of Public Health and Environment, Denver (N.C.); Washin
  • Newberry LA; From the Centers for Disease Control and Prevention (S.J.C., L.B., L.W., A.B., M.N.S., D.W., E.T., M.E.W., K.P.N.), and IHRC (L.B., D.W.), Atlanta; Food and Drug Administration, College Park, MD (L.N.S., B.M.W., J.B., S.V.); Colorado Department of Public Health and Environment, Denver (N.C.); Washin
  • Schroeder MN; From the Centers for Disease Control and Prevention (S.J.C., L.B., L.W., A.B., M.N.S., D.W., E.T., M.E.W., K.P.N.), and IHRC (L.B., D.W.), Atlanta; Food and Drug Administration, College Park, MD (L.N.S., B.M.W., J.B., S.V.); Colorado Department of Public Health and Environment, Denver (N.C.); Washin
  • Wagner D; From the Centers for Disease Control and Prevention (S.J.C., L.B., L.W., A.B., M.N.S., D.W., E.T., M.E.W., K.P.N.), and IHRC (L.B., D.W.), Atlanta; Food and Drug Administration, College Park, MD (L.N.S., B.M.W., J.B., S.V.); Colorado Department of Public Health and Environment, Denver (N.C.); Washin
  • Trees E; From the Centers for Disease Control and Prevention (S.J.C., L.B., L.W., A.B., M.N.S., D.W., E.T., M.E.W., K.P.N.), and IHRC (L.B., D.W.), Atlanta; Food and Drug Administration, College Park, MD (L.N.S., B.M.W., J.B., S.V.); Colorado Department of Public Health and Environment, Denver (N.C.); Washin
  • Viazis S; From the Centers for Disease Control and Prevention (S.J.C., L.B., L.W., A.B., M.N.S., D.W., E.T., M.E.W., K.P.N.), and IHRC (L.B., D.W.), Atlanta; Food and Drug Administration, College Park, MD (L.N.S., B.M.W., J.B., S.V.); Colorado Department of Public Health and Environment, Denver (N.C.); Washin
  • Wise ME; From the Centers for Disease Control and Prevention (S.J.C., L.B., L.W., A.B., M.N.S., D.W., E.T., M.E.W., K.P.N.), and IHRC (L.B., D.W.), Atlanta; Food and Drug Administration, College Park, MD (L.N.S., B.M.W., J.B., S.V.); Colorado Department of Public Health and Environment, Denver (N.C.); Washin
  • Neil KP; From the Centers for Disease Control and Prevention (S.J.C., L.B., L.W., A.B., M.N.S., D.W., E.T., M.E.W., K.P.N.), and IHRC (L.B., D.W.), Atlanta; Food and Drug Administration, College Park, MD (L.N.S., B.M.W., J.B., S.V.); Colorado Department of Public Health and Environment, Denver (N.C.); Washin
N Engl J Med ; 377(21): 2036-2043, 2017 11 23.
Article em En | MEDLINE | ID: mdl-29166238
BACKGROUND: In 2016, a multijurisdictional team investigated an outbreak of Shiga toxin-producing Escherichia coli (STEC) serogroup O121 and O26 infections linked to contaminated flour from a large domestic producer. METHODS: A case was defined as infection with an outbreak strain in which illness onset was between December 21, 2015, and September 5, 2016. To identify exposures associated with the outbreak, outbreak cases were compared with non-STEC enteric illness cases, matched according to age group, sex, and state of residence. Products suspected to be related to the outbreak were collected for STEC testing, and a common point of contamination was sought. Whole-genome sequencing was performed on isolates from clinical and food samples. RESULTS: A total of 56 cases were identified in 24 states. Univariable exact conditional logistic-regression models of 22 matched sets showed that infection was significantly associated with the use of one brand of flour (odds ratio, 21.04; 95% confidence interval [CI], 4.69 to 94.37) and with tasting unbaked homemade dough or batter (odds ratio, 36.02; 95% CI, 4.63 to 280.17). Laboratory testing isolated the outbreak strains from flour samples, and whole-genome sequencing revealed that the isolates from clinical and food samples were closely related to one another genetically. Trace-back investigation identified a common flour-production facility. CONCLUSIONS: This investigation implicated raw flour as the source of an outbreak of STEC infections. Although it is a low-moisture food, raw flour can be a vehicle for foodborne pathogens.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Surtos de Doenças / Infecções por Escherichia coli / Escherichia coli Shiga Toxigênica / Farinha / Microbiologia de Alimentos / Doenças Transmitidas por Alimentos Tipo de estudo: Risk_factors_studies Limite: Adolescent / Adult / Aged / Aged80 / Child / Child, preschool / Female / Humans / Infant / Male País como assunto: America do norte Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Surtos de Doenças / Infecções por Escherichia coli / Escherichia coli Shiga Toxigênica / Farinha / Microbiologia de Alimentos / Doenças Transmitidas por Alimentos Tipo de estudo: Risk_factors_studies Limite: Adolescent / Adult / Aged / Aged80 / Child / Child, preschool / Female / Humans / Infant / Male País como assunto: America do norte Idioma: En Ano de publicação: 2017 Tipo de documento: Article