Lixisenatide reduces amyloid plaques, neurofibrillary tangles and neuroinflammation in an APP/PS1/tau mouse model of Alzheimer's disease.

Cai, Hong-Yan; Yang, Jun-Ting; Wang, Zhao-Jun; Zhang, Jun; Yang, Wei; Wu, Mei-Na; Qi, Jin-Shun

Cai, Hong-Yan; Yang, Jun-Ting; Wang, Zhao-Jun; Zhang, Jun; Yang, Wei; Wu, Mei-Na; Qi, Jin-Shun.

Afiliação

Cai HY; Department of Microbiology and Immunology, Shanxi Medical University, 56 Xinjian South Road, Taiyuan, Shanxi Province, 030001, China. Electronic address: yancai1@163.com.
Yang JT; Department of Physiology, Shanxi Medical University, 56 Xinjian South Road, Taiyuan, Shanxi Province, 030001, China. Electronic address: 984647776@qq.com.
Wang ZJ; Department of Physiology, Shanxi Medical University, 56 Xinjian South Road, Taiyuan, Shanxi Province, 030001, China. Electronic address: wzhaojun1025@126.com.
Zhang J; Department of Physiology, Shanxi Medical University, 56 Xinjian South Road, Taiyuan, Shanxi Province, 030001, China. Electronic address: zj2004081@163.com.
Yang W; Department of Physiology, Shanxi Medical University, 56 Xinjian South Road, Taiyuan, Shanxi Province, 030001, China. Electronic address: vividmail@163.com.
Wu MN; Department of Physiology, Shanxi Medical University, 56 Xinjian South Road, Taiyuan, Shanxi Province, 030001, China. Electronic address: wmna@163.com.
Qi JS; Department of Physiology, Shanxi Medical University, 56 Xinjian South Road, Taiyuan, Shanxi Province, 030001, China. Electronic address: jinshunqi2009@163.com.

Biochem Biophys Res Commun ; 495(1): 1034-1040, 2018 01 01.

Article em En | MEDLINE | ID: mdl-29175324

Assuntos

Doença de Alzheimer/tratamento farmacológico; Doença de Alzheimer/metabolismo; Encefalite/tratamento farmacológico; Encefalite/metabolismo; Emaranhados Neurofibrilares/efeitos dos fármacos; Peptídeos/administração & dosagem; Doença de Alzheimer/patologia; Precursor de Proteína beta-Amiloide/genética; Animais; Relação Dose-Resposta a Droga; Encefalite/patologia; Feminino; Receptor do Peptídeo Semelhante ao Glucagon 1/agonistas; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Transgênicos; Emaranhados Neurofibrilares/metabolismo; Emaranhados Neurofibrilares/patologia; Fármacos Neuroprotetores/administração & dosagem; Resultado do Tratamento

Palavras-chave

Alzheimer's disease; Amyloid plaques; Lixisenatide; Neurofibrillary tangles; Neuroinflammation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos / Emaranhados Neurofibrilares / Encefalite / Doença de Alzheimer Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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