[Application of Liquid Biopsy for Lung Cancer Treatment.]
Rinsho Byori
; 64(4): 407-411, 2016 May.
Article
em Ja
| MEDLINE
| ID: mdl-29182807
ABSTRACT
Liquid biopsy is defined as a non-invasive blood test that detects features of tumor cells, which are shed into the blood stream from the primary tumor and/or metastatic sites. This method is developing based on research on circulating tumor cells (CTCs) and the circulating free/fragments of tumor DNA (cfDNA). CfDNA can be detected in the absence of detectable CTCs, and has been shown to increase with the disease condition. The detection of cfDNA can be used for tumor genotyping, monitoring of the tumor burden, and monitoring minimal residual diseases, and recent results showed that cfDNA is a highly specific biomarker with intermediate sensitivity. Liquid biopsy with cfDNA is promising, and is becoming an alternative to re- biopsy. However, there are some caveats it has not been elucidated which patients and tumor types can be accessed with cfDNA. Further research is warranted.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Pulmonares
Idioma:
Ja
Ano de publicação:
2016
Tipo de documento:
Article