Isocanthine Synthesis via Rh(III)-Catalyzed Intramolecular C-H Functionalization.
J Org Chem
; 83(1): 330-337, 2018 01 05.
Article
em En
| MEDLINE
| ID: mdl-29182872
ABSTRACT
An efficient synthesis of substituted isocanthines has been achieved using an intramolecular Rh(III)-catalyzed C-H functionalization of alkyne-tethered indoles in the presence of catalytic tris(acetonitrile)pentamethylcyclopentadienylrhodium(III) hexafluoroantimonate and stoichiometric copper(II) acetate. This isocanthine synthesis tolerates a variety of electronically diverse 5- or 6-substituted indoles with N-tethered alkyne coupling partners and can also be extended to pyrrole derivatives for the synthesis of annulated 5-azaindoles.
Texto completo:
1
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article