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Halistanol sulfates I and J, new SIRT1-3 inhibitory steroid sulfates from a marine sponge of the genus Halichondria.
Nakamura, Fumiaki; Kudo, Norio; Tomachi, Yuki; Nakata, Akiko; Takemoto, Misao; Ito, Akihiro; Tabei, Hodaka; Arai, Daisuke; de Voogd, Nicole; Yoshida, Minoru; Nakao, Yoichi; Fusetani, Nobuhiro.
Afiliação
  • Nakamura F; Department of Chemistry and Biochemistry, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, Japan.
  • Kudo N; Seed Compounds Exploratory Unit for Drug Discovery Platform, RIKEN Center for Sustainable Resource Science, Saitama, Japan.
  • Tomachi Y; Department of Chemistry and Biochemistry, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, Japan.
  • Nakata A; Seed Compounds Exploratory Unit for Drug Discovery Platform, RIKEN Center for Sustainable Resource Science, Saitama, Japan.
  • Takemoto M; Seed Compounds Exploratory Unit for Drug Discovery Platform, RIKEN Center for Sustainable Resource Science, Saitama, Japan.
  • Ito A; Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science, Saitama, Japan.
  • Tabei H; School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan.
  • Arai D; Department of Chemistry and Biochemistry, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, Japan.
  • de Voogd N; Research Institute for Science and Engineering, Waseda University, Tokyo, Japan.
  • Yoshida M; Naturalis Biodiversity Center, Leiden, The Netherlands.
  • Nakao Y; Seed Compounds Exploratory Unit for Drug Discovery Platform, RIKEN Center for Sustainable Resource Science, Saitama, Japan.
  • Fusetani N; Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science, Saitama, Japan.
J Antibiot (Tokyo) ; 71(2): 273-278, 2018 02.
Article em En | MEDLINE | ID: mdl-29184120
ABSTRACT
Two new analogs of halistanol sulfate (1) were isolated from a marine sponge Halichondria sp. collected at Hachijo-jima Island. Structures of these new halistanol sulfates I (2) and J (3) were elucidated by spectral analyses. Compounds 1-3 showed inhibitory activity against SIRT 1-3 with IC50 ranges of 45.9-67.9, 18.9-21.1 and 21.8-37.5 µM, respectively. X-ray crystallography of the halistanol sulfate (1) and SIRT3 complex clearly indicates that 1 binds to the exosite of SIRT3 that we have discovered in this study.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Poríferos / Esteróis / Sirtuínas Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Poríferos / Esteróis / Sirtuínas Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article