JQ1, a BET inhibitor, controls TLR4-induced IL-10 production in regulatory B cells by BRD4-NF-κB axis.
BMB Rep
; 50(12): 640-646, 2017 Dec.
Article
em En
| MEDLINE
| ID: mdl-29187284
ABSTRACT
Regulatory B cells, also well-known as IL-10-producing B cells, play a role in the suppression of inflammatory responses. However, the epigenetic modulation of regulatory B cells is largely unknown. Recent studies showed that the bromodomain and extra-terminal domain (BET) protein inhibitor JQ1 controls the expression of various genes involving cell proliferation and cell cycle. However, the role of BET proteins on development of regulatory B cells is not reported. In this study, JQ1 potently suppressed IL-10 expression and secretion in murine splenic and peritoneal B cells. While bromodomaincontaining protein 4 (BRD4) was associated with NF-κB on IL-10 promoter region by LPS stimulation, JQ1 interfered the interaction of BRD4 with NF-κB on IL-10 promoter. In summary, BRD4 is essential for toll like receptor 4 (TLR4)-mediated IL-10 expression, suggesting JQ1 could be a potential candidate in regulating IL-10-producing regulatory B cells in cancer. [BMB Reports 2017; 50(12) 640-646].
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Azepinas
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Fatores de Transcrição
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Triazóis
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Proteínas Nucleares
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NF-kappa B
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Interleucina-10
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Receptor 4 Toll-Like
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Linfócitos B Reguladores
Limite:
Animals
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article