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Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility.
Sud, Amit; Thomsen, Hauke; Law, Philip J; Försti, Asta; Filho, Miguel Inacio da Silva; Holroyd, Amy; Broderick, Peter; Orlando, Giulia; Lenive, Oleg; Wright, Lauren; Cooke, Rosie; Easton, Douglas; Pharoah, Paul; Dunning, Alison; Peto, Julian; Canzian, Federico; Eeles, Rosalind; Kote-Jarai, ZSofia; Muir, Kenneth; Pashayan, Nora; Hoffmann, Per; Nöthen, Markus M; Jöckel, Karl-Heinz; Strandmann, Elke Pogge von; Lightfoot, Tracy; Kane, Eleanor; Roman, Eve; Lake, Annette; Montgomery, Dorothy; Jarrett, Ruth F; Swerdlow, Anthony J; Engert, Andreas; Orr, Nick; Hemminki, Kari; Houlston, Richard S.
Afiliação
  • Sud A; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.
  • Thomsen H; Division of Molecular Genetic Epidemiology, German Cancer Research Centre, Heidelberg, 69120, Germany.
  • Law PJ; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.
  • Försti A; Division of Molecular Genetic Epidemiology, German Cancer Research Centre, Heidelberg, 69120, Germany.
  • Filho MIDS; Centre for Primary Health Care Research, Lund University, Malmö, 221 00, Sweden.
  • Holroyd A; Division of Molecular Genetic Epidemiology, German Cancer Research Centre, Heidelberg, 69120, Germany.
  • Broderick P; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.
  • Orlando G; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.
  • Lenive O; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.
  • Wright L; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.
  • Cooke R; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.
  • Easton D; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.
  • Pharoah P; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, CB1 8RN, UK.
  • Dunning A; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.
  • Peto J; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, CB1 8RN, UK.
  • Canzian F; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.
  • Eeles R; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, CB1 8RN, UK.
  • Kote-Jarai Z; Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK.
  • Muir K; Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany.
  • Pashayan N; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.
  • Hoffmann P; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.
  • Nöthen MM; Institute of Population Health, University of Manchester, Manchester, M1 3BB, UK.
  • Jöckel KH; Division of Health Sciences, Warwick Medical School, Warwick University, Warwick, CV4 7AL, UK.
  • Strandmann EPV; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.
  • Lightfoot T; Department of Applied Health Research, University College London, London, WC1E 7HB, UK.
  • Roman E; Department of Biomedicine, Division of Medical Genetics, University of Basel, Basel, 4031, Switzerland.
  • Lake A; Institute of Human Genetics, University of Bonn, Bonn, 53127, Germany.
  • Montgomery D; Institute of Human Genetics, University of Bonn, Bonn, 53127, Germany.
  • Jarrett RF; Department of Genomics, Life & Brain Center, University of Bonn, Bonn, 53127, Germany.
  • Swerdlow AJ; University of Duisburg-Essen, Essen, 47057, Germany.
  • Engert A; Department of Internal Medicine, University Hospital of Cologne, Cologne, 50937, Germany.
  • Orr N; Department of Health Sciences, University of York, York, YO10 5DD, UK.
  • Hemminki K; Department of Health Sciences, University of York, York, YO10 5DD, UK.
  • Houlston RS; Department of Health Sciences, University of York, York, YO10 5DD, UK.
Nat Commun ; 8(1): 1892, 2017 12 01.
Article em En | MEDLINE | ID: mdl-29196614
ABSTRACT
Several susceptibility loci for classical Hodgkin lymphoma have been reported. However, much of the heritable risk is unknown. Here, we perform a meta-analysis of two existing genome-wide association studies, a new genome-wide association study, and replication totalling 5,314 cases and 16,749 controls. We identify risk loci for all classical Hodgkin lymphoma at 6q22.33 (rs9482849, P = 1.52 × 10-8) and for nodular sclerosis Hodgkin lymphoma at 3q28 (rs4459895, P = 9.43 × 10-17), 6q23.3 (rs6928977, P = 4.62 × 10-11), 10p14 (rs3781093, P = 9.49 × 10-13), 13q34 (rs112998813, P = 4.58 × 10-8) and 16p13.13 (rs34972832, P = 2.12 × 10-8). Additionally, independent loci within the HLA region are observed for nodular sclerosis Hodgkin lymphoma (rs9269081, HLA-DPB1*0301, Val86 in HLA-DRB1) and mixed cellularity Hodgkin lymphoma (rs1633096, rs13196329, Val86 in HLA-DRB1). The new and established risk loci localise to areas of active chromatin and show an over-representation of transcription factor binding for determinants of B-cell development and immune response.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Hodgkin / Predisposição Genética para Doença Tipo de estudo: Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Hodgkin / Predisposição Genética para Doença Tipo de estudo: Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article