Cardiac Toxicity After Craniospinal Irradiation: A Late Effect That May be Eliminated With Proton Therapy.
J Pediatr Hematol Oncol
; 40(5): e330-e333, 2018 07.
Article
em En
| MEDLINE
| ID: mdl-29200158
ABSTRACT
BACKGROUND:
Craniospinal irradiation (CSI) is commonly required for pediatric patients with central nervous system malignancies. Traditionally, CSI is given using x-rays to deliver radiation to the brain and spine, exposing normal anterior structures, including heart, to unnecessary radiation. OBSERVATIONS We present a patient treated with x-ray CSI for medulloblastoma with spinal metastasis (3600 cGy CSI with focal boost to 5000 cGy), who subsequently developed significant cardiac toxicity, likely related to radiation exposure.CONCLUSIONS:
Spinal irradiation can cause significant cardiac risk due to exit dose through anterior structures. This toxicity may be avoided with proton therapy, which eliminates visceral exit dose.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Lesões por Radiação
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Neoplasias da Medula Espinal
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Radiação Cranioespinal
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Cardiotoxicidade
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Meduloblastoma
Limite:
Child, preschool
/
Humans
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Male
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article