Aldosterone-Producing Cell Clusters in Normal and Pathological States.
Horm Metab Res
; 49(12): 951-956, 2017 Dec.
Article
em En
| MEDLINE
| ID: mdl-29202494
ABSTRACT
Primary aldosteronism (PA) significantly increases the risk of cardiovascular complications, and early diagnosis and targeted treatment based on its pathophysiology is warranted. Next-generation sequencing (NGS) has revealed recurrent somatic mutations in aldosterone-driving genes in aldosterone-producing adenoma (APA). By applying CYP11B2 (aldosterone synthase) immunohistochemistry and NGS to adrenal glands from normal subjects and PA patients, we and others have shown that CYP11B2-positive cells make small clusters, termed aldosterone-producing cell clusters (APCC), beneath the adrenal capsule, and that APCC harbor somatic mutations in genes mutated in APA. We have shown that APCC are increased in CT-negative PA adrenals, while others showed potential progression from APCC to micro APA through mutations. These results suggest that APCC are a key factor for understanding the origin of PA, and further investigation on the relation between APCC and PA is highly needed.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Adenoma
/
Neoplasias do Córtex Suprarrenal
/
Glândulas Suprarrenais
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Aldosterona
/
Hiperaldosteronismo
Tipo de estudo:
Screening_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article