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Islet cells share promoter hypomethylation independently of expression, but exhibit cell-type-specific methylation in enhancers.
Neiman, Daniel; Moss, Joshua; Hecht, Merav; Magenheim, Judith; Piyanzin, Sheina; Shapiro, A M James; de Koning, Eelco J P; Razin, Aharon; Cedar, Howard; Shemer, Ruth; Dor, Yuval.
Afiliação
  • Neiman D; Department of Developmental Biology and Cancer Research, Institute For Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel.
  • Moss J; Department of Developmental Biology and Cancer Research, Institute For Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel.
  • Hecht M; Department of Developmental Biology and Cancer Research, Institute For Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel.
  • Magenheim J; Department of Developmental Biology and Cancer Research, Institute For Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel.
  • Piyanzin S; Department of Developmental Biology and Cancer Research, Institute For Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel.
  • Shapiro AMJ; Department of Surgery and the Clinical Islet Transplant Program, University of Alberta, Edmonton, AB T6G 2C8, Canada.
  • de Koning EJP; Department of Internal Medicine, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
  • Razin A; Hubrecht Institute-Royal Netherlands Academy of Arts and Sciences (KNAW), University Medical Center Utrecht, 3584 CT Utrecht, The Netherlands.
  • Cedar H; Department of Developmental Biology and Cancer Research, Institute For Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel.
  • Shemer R; Department of Developmental Biology and Cancer Research, Institute For Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel.
  • Dor Y; Department of Developmental Biology and Cancer Research, Institute For Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel; shemer.ru@mail.huji.ac.il yuvald@ekmd.huji.ac.il.
Proc Natl Acad Sci U S A ; 114(51): 13525-13530, 2017 12 19.
Article em En | MEDLINE | ID: mdl-29203669
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Elementos Facilitadores Genéticos / Regiões Promotoras Genéticas / Metilação de DNA / Células Secretoras de Glucagon / Células Secretoras de Insulina Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Elementos Facilitadores Genéticos / Regiões Promotoras Genéticas / Metilação de DNA / Células Secretoras de Glucagon / Células Secretoras de Insulina Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article