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Efficient Buchwald-Hartwig-Migita Cross-Coupling for DNA Thioglycoconjugation.
Probst, Nicolas; Lartia, Rémy; Théry, Océane; Alami, Mouâd; Defrancq, Eric; Messaoudi, Samir.
Afiliação
  • Probst N; BioCIS, Univ. Paris-Sud, CNRS, University Paris-Saclay, 92290, Châtenay-Malabry, France.
  • Lartia R; University Grenoble-Alpes, DCM, CS 40700, 38058, Grenoble, France.
  • Théry O; University Grenoble-Alpes, DCM, CS 40700, 38058, Grenoble, France.
  • Alami M; BioCIS, Univ. Paris-Sud, CNRS, University Paris-Saclay, 92290, Châtenay-Malabry, France.
  • Defrancq E; University Grenoble-Alpes, DCM, CS 40700, 38058, Grenoble, France.
  • Messaoudi S; BioCIS, Univ. Paris-Sud, CNRS, University Paris-Saclay, 92290, Châtenay-Malabry, France.
Chemistry ; 24(8): 1795-1800, 2018 Feb 06.
Article em En | MEDLINE | ID: mdl-29205564
ABSTRACT
An efficient method for the thioglycoconjugation of iodinated oligonucleotides by Buchwald-Hartwig-Migita cross-coupling under mild conditions is reported. The method enables divergent synthesis of many different functionalized thioglycosylated ODNs in good yields, without affecting the integrity of the other A, C, and G nucleobases.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oligonucleotídeos / Compostos de Sulfidrila Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oligonucleotídeos / Compostos de Sulfidrila Idioma: En Ano de publicação: 2018 Tipo de documento: Article