Efficient Buchwald-Hartwig-Migita Cross-Coupling for DNA Thioglycoconjugation.
Chemistry
; 24(8): 1795-1800, 2018 Feb 06.
Article
em En
| MEDLINE
| ID: mdl-29205564
ABSTRACT
An efficient method for the thioglycoconjugation of iodinated oligonucleotides by Buchwald-Hartwig-Migita cross-coupling under mild conditions is reported. The method enables divergent synthesis of many different functionalized thioglycosylated ODNs in good yields, without affecting the integrity of the other A, C, and G nucleobases.
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Base de dados:
MEDLINE
Assunto principal:
Oligonucleotídeos
/
Compostos de Sulfidrila
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article