Chetomin induces apoptosis in human triple-negative breast cancer cells by promoting calcium overload and mitochondrial dysfunction.

Dewangan, Jayant; Srivastava, Sonal; Mishra, Sakshi; Pandey, Prabhash Kumar; Divakar, Aman; Rath, Srikanta Kumar

Dewangan, Jayant; Srivastava, Sonal; Mishra, Sakshi; Pandey, Prabhash Kumar; Divakar, Aman; Rath, Srikanta Kumar.

Afiliação

Dewangan J; Genotoxicity Lab, Division of Toxicology and Experimental Medicine, CSIR-Central Drug Research Institute, Lucknow, 226031, Uttar Pradesh, India. Electronic address: jayantdewangan@gmail.com.
Srivastava S; Genotoxicity Lab, Division of Toxicology and Experimental Medicine, CSIR-Central Drug Research Institute, Lucknow, 226031, Uttar Pradesh, India. Electronic address: sonal.srivastava24@gmail.com.
Mishra S; Genotoxicity Lab, Division of Toxicology and Experimental Medicine, CSIR-Central Drug Research Institute, Lucknow, 226031, Uttar Pradesh, India. Electronic address: drsakshimishra@gmail.com.
Pandey PK; Genotoxicity Lab, Division of Toxicology and Experimental Medicine, CSIR-Central Drug Research Institute, Lucknow, 226031, Uttar Pradesh, India. Electronic address: pandey.prabhash21@gmail.com.
Divakar A; Genotoxicity Lab, Division of Toxicology and Experimental Medicine, CSIR-Central Drug Research Institute, Lucknow, 226031, Uttar Pradesh, India. Electronic address: amandivakar@gmail.com.
Rath SK; Genotoxicity Lab, Division of Toxicology and Experimental Medicine, CSIR-Central Drug Research Institute, Lucknow, 226031, Uttar Pradesh, India. Electronic address: skrath@cdri.res.in.

Biochem Biophys Res Commun ; 495(2): 1915-1921, 2018 01 08.

Article em En | MEDLINE | ID: mdl-29208466

Assuntos

Apoptose/efeitos dos fármacos; Cálcio/metabolismo; Dissulfetos/administração & dosagem; Alcaloides Indólicos/administração & dosagem; Mitocôndrias/efeitos dos fármacos; Mitocôndrias/patologia; Neoplasias de Mama Triplo Negativas/tratamento farmacológico; Neoplasias de Mama Triplo Negativas/metabolismo; Antineoplásicos/administração & dosagem; Linhagem Celular Tumoral; Relação Dose-Resposta a Droga; Humanos; Resultado do Tratamento; Neoplasias de Mama Triplo Negativas/patologia

Palavras-chave

Apoptosis; BAPTA-AM; Calcium; Chetomin; Triple-negative breast cancer

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cálcio / Apoptose / Alcaloides Indólicos / Dissulfetos / Neoplasias de Mama Triplo Negativas / Mitocôndrias Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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