The diphenylpyrazole compound anle138b blocks Aß channels and rescues disease phenotypes in a mouse model for amyloid pathology.
EMBO Mol Med
; 10(1): 32-47, 2018 01.
Article
em En
| MEDLINE
| ID: mdl-29208638
ABSTRACT
Alzheimer's disease is a devastating neurodegenerative disease eventually leading to dementia. An effective treatment does not yet exist. Here we show that oral application of the compound anle138b restores hippocampal synaptic and transcriptional plasticity as well as spatial memory in a mouse model for Alzheimer's disease, when given orally before or after the onset of pathology. At the mechanistic level, we provide evidence that anle138b blocks the activity of conducting Aß pores without changing the membrane embedded Aß-oligomer structure. In conclusion, our data suggest that anle138b is a novel and promising compound to treat AD-related pathology that should be investigated further.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pirazóis
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Peptídeos beta-Amiloides
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Benzodioxóis
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Doença de Alzheimer
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Hipocampo
Limite:
Animals
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article