Stable Isotope Pharmacokinetic Studies Provide Insight into Effects of Age, Sex, and Weight on Levothyroxine Metabolism.

Younis, Islam R; Ahmed, Mariam A; Burman, Kenneth D; Soldin, Offie P; Jonklaas, Jacqueline

Younis, Islam R; Ahmed, Mariam A; Burman, Kenneth D; Soldin, Offie P; Jonklaas, Jacqueline.

Afiliação

Younis IR; 1 Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research , U.S. Food and Drug Administration, Silver Spring, Maryland.
Ahmed MA; 1 Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research , U.S. Food and Drug Administration, Silver Spring, Maryland.
Burman KD; 2 Section of Endocrinology, MedStar Washington Hospital Center , Washington, DC.
Soldin OP; 3 Departments of Medicine, Oncology, Physiology, and Biophysics, Georgetown University Medical Center , Washington, DC.
Jonklaas J; 4 Division of Endocrinology, Georgetown University Medical Center , Washington, DC.

Thyroid ; 28(1): 41-49, 2018 01.

Article em En | MEDLINE | ID: mdl-29212434

Assuntos

Peso Corporal/fisiologia; Hipotireoidismo/tratamento farmacológico; Tiroxina/farmacocinética; Administração Oral; Adulto; Fatores Etários; Idoso; Relação Dose-Resposta a Droga; Feminino; Humanos; Masculino; Taxa de Depuração Metabólica; Pessoa de Meia-Idade; Fatores Sexuais; Tiroxina/uso terapêutico; Adulto Jovem

Palavras-chave

aging; clearance; levothyroxine; metabolism; weight

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tiroxina / Peso Corporal / Hipotireoidismo Tipo de estudo: Prognostic_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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