Etiology and Genetics of Congenital Vascular Lesions.
Otolaryngol Clin North Am
; 51(1): 41-53, 2018 Feb.
Article
em En
| MEDLINE
| ID: mdl-29217067
ABSTRACT
The detection of somatic, activating genetic mutations to underlie development of vascular tumors and malformations led to a better understanding of their pathophysiology. Proteins encoded by the detected mutated genes activate the two major signaling pathways, also involved in cancer the RAS/MAPK/ERK pathway and/or the PI3K/AKT/mTOR pathway. This gives a strong basis for studies to repurpose cancer therapeutics to patients with vascular tumors and malformations.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Malformações Arteriovenosas
/
Transdução de Sinais
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Anormalidades Linfáticas
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Neoplasias de Cabeça e Pescoço
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Hemangioma
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article