An Animal Model of Alzheimer Disease Based on the Intrahippocampal Injection of Amyloid ß-Peptide (1-42).
Methods Mol Biol
; 1727: 343-352, 2018.
Article
em En
| MEDLINE
| ID: mdl-29222793
ABSTRACT
The intrahippocampal injection of amyloid beta peptide (1-42) (Aß(1-42)) represents one of the most useful animal models of Alzheimer disease. Since none of these available models fully represents the main pathological hallmarks of Alzheimer disease, stereotaxic Aß(1-42) infusion provides researchers with an in vivo alternative paradigm. When performed by well-trained individuals, this model is the best-suited one for short-term studies focusing on the effects of Aß(1-42) on a specific brain region or circuitry. Here, we describe all methodological phases of such a model.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptídeos beta-Amiloides
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Modelos Animais de Doenças
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Doença de Alzheimer
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article