High-level expression and immunogenicity of porcine circovirus type 2b capsid protein without nuclear localization signal expressed in Hansenula polymorpha.

Xiao, Yue; Zhao, Peiyan; Du, Junyang; Li, Xin; Lu, Wenting; Hao, Xu; Dong, Boqi; Yu, Yongli; Wang, Liying

Xiao, Yue; Zhao, Peiyan; Du, Junyang; Li, Xin; Lu, Wenting; Hao, Xu; Dong, Boqi; Yu, Yongli; Wang, Liying.

Afiliação

Xiao Y; Department of Molecular Biology in College of Basic Medical Sciences and Institute of Pediatrics in First Hospital, Jilin University, Changchun 130021, China.
Zhao P; Department of Molecular Biology in College of Basic Medical Sciences and Institute of Pediatrics in First Hospital, Jilin University, Changchun 130021, China.
Du J; Department of Immunology in College of Basic Medical Sciences, Jilin University, Changchun 130021, China.
Li X; Department of Molecular Biology in College of Basic Medical Sciences and Institute of Pediatrics in First Hospital, Jilin University, Changchun 130021, China.
Lu W; Department of Molecular Biology in College of Basic Medical Sciences and Institute of Pediatrics in First Hospital, Jilin University, Changchun 130021, China.
Hao X; Department of Immunology in College of Basic Medical Sciences, Jilin University, Changchun 130021, China.
Dong B; Department of Immunology in College of Basic Medical Sciences, Jilin University, Changchun 130021, China.
Yu Y; Department of Immunology in College of Basic Medical Sciences, Jilin University, Changchun 130021, China. Electronic address: ylyu@jlu.edu.cn.
Wang L; Department of Molecular Biology in College of Basic Medical Sciences and Institute of Pediatrics in First Hospital, Jilin University, Changchun 130021, China. Electronic address: wlying@mail.jlu.edu.cn.

Biologicals ; 51: 18-24, 2018 Jan.

Article em En | MEDLINE | ID: mdl-29225046

Assuntos

Proteínas do Capsídeo/imunologia; Circovirus/imunologia; Expressão Gênica/imunologia; Sinais de Localização Nuclear/imunologia; Animais; Anticorpos Antivirais/imunologia; Proteínas do Capsídeo/genética; Proteínas do Capsídeo/ultraestrutura; Infecções por Circoviridae/imunologia; Infecções por Circoviridae/virologia; Circovirus/genética; Circovirus/metabolismo; Feminino; Camundongos Endogâmicos BALB C; Sinais de Localização Nuclear/genética; Pichia/genética; Proteínas Recombinantes/imunologia; Deleção de Sequência; Suínos; Vacinação; Vacinas Virais/genética; Vacinas Virais/imunologia

Palavras-chave

Hansenula polymorpha; Immunogenicity; Nuclear localization signal; Porcine circovirus type 2b; Purification

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Expressão Gênica / Circovirus / Sinais de Localização Nuclear / Proteínas do Capsídeo Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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