Regulatory networks specifying cortical interneurons from human embryonic stem cells reveal roles for CHD2 in interneuron development.

Meganathan, Kesavan; Lewis, Emily M A; Gontarz, Paul; Liu, Shaopeng; Stanley, Edouard G; Elefanty, Andrew G; Huettner, James E; Zhang, Bo; Kroll, Kristen L

Meganathan, Kesavan; Lewis, Emily M A; Gontarz, Paul; Liu, Shaopeng; Stanley, Edouard G; Elefanty, Andrew G; Huettner, James E; Zhang, Bo; Kroll, Kristen L.

Afiliação

Meganathan K; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110.
Lewis EMA; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110.
Gontarz P; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110.
Liu S; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110.
Stanley EG; Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, VIC 3052, Australia.
Elefanty AG; Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, VIC 3052, Australia.
Huettner JE; Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110.
Zhang B; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110.
Kroll KL; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110; kkroll@wustl.edu.

Proc Natl Acad Sci U S A ; 114(52): E11180-E11189, 2017 12 26.

Article em En | MEDLINE | ID: mdl-29229852

Assuntos

Diferenciação Celular; Córtex Cerebral/metabolismo; Proteínas de Ligação a DNA/metabolismo; Células-Tronco Embrionárias Humanas/metabolismo; Interneurônios/metabolismo; Linhagem Celular; Córtex Cerebral/citologia; Proteínas de Ligação a DNA/genética; Células-Tronco Embrionárias Humanas/citologia; Humanos; Interneurônios/citologia; Fator Nuclear 1 de Tireoide/genética; Fator Nuclear 1 de Tireoide/metabolismo

Palavras-chave

CHD2; NKX2-1; cortical interneurons; human embryonic stem cells; medial ganglionic eminence

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Diferenciação Celular / Córtex Cerebral / Proteínas de Ligação a DNA / Células-Tronco Embrionárias Humanas / Interneurônios Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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