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Appetite suppressive role of medial septal glutamatergic neurons.
Sweeney, Patrick; Li, Changhong; Yang, Yunlei.
Afiliação
  • Sweeney P; Department of Neuroscience and Physiology, State University of New York Upstate Medical University, Syracuse, NY 13210.
  • Li C; Department of Neuroscience and Physiology, State University of New York Upstate Medical University, Syracuse, NY 13210.
  • Yang Y; Department of Neurology, Beijing Haidian Hospital, Beijing, 100080, People's Republic of China.
Proc Natl Acad Sci U S A ; 114(52): 13816-13821, 2017 12 26.
Article em En | MEDLINE | ID: mdl-29229861
Feeding behavior is controlled by diverse neurons and neural circuits primarily concentrated in the hypothalamus and hindbrain in mammals. In this study, by using chemo/optogenetic techniques along with feeding assays, we investigate how neurons within the medial septal complex (MSc), a brain area implicated in emotion and cognition, contribute to food intake. We find that chemo/optogenetic activation of MSc glutamatergic neurons profoundly reduces food intake during both light and dark periods of the rodent light cycle. Furthermore, we find that selective activation of MSc glutamatergic projections in paraventricular hypothalamus (PVH) reduces food intake, suggesting that MSc glutamatergic neurons suppress feeding by activating downstream neurons in the PVH. Open-field behavioral assays reveal that these neurons do not overtly affect anxiety levels and locomotion. Collectively, our findings demonstrate that septal glutamatergic neurons exert anorexigenic effects by projecting to the PVH without affecting anxiety and physical activities.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Regulação do Apetite / Núcleos Septais / Ingestão de Alimentos / Locomoção / Neurônios Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Regulação do Apetite / Núcleos Septais / Ingestão de Alimentos / Locomoção / Neurônios Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article