Regulation of developing myelin sheath elongation by oligodendrocyte calcium transients in vivo.
Nat Neurosci
; 21(1): 24-28, 2018 01.
Article
em En
| MEDLINE
| ID: mdl-29230052
ABSTRACT
How action potentials regulate myelination by oligodendrocytes is uncertain. We show that neuronal activity raises [Ca2+]i in developing oligodendrocytes in vivo and that myelin sheath elongation is promoted by a high frequency of [Ca2+]i transients and prevented by [Ca2+]i buffering. Sheath elongation occurs ~1 h after [Ca2+]i elevation. Sheath shortening is associated with a low frequency of [Ca2+]i transients but with longer duration [Ca2+]i bursts. Thus, [Ca2+]i controls myelin sheath development.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Axônios
/
Oligodendroglia
/
Cálcio
/
Bainha de Mielina
/
Neurônios
Limite:
Animals
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article