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Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia.
Jiang, Xi; Hu, Chao; Ferchen, Kyle; Nie, Ji; Cui, Xiaolong; Chen, Chih-Hong; Cheng, Liting; Zuo, Zhixiang; Seibel, William; He, Chunjiang; Tang, Yixuan; Skibbe, Jennifer R; Wunderlich, Mark; Reinhold, William C; Dong, Lei; Shen, Chao; Arnovitz, Stephen; Ulrich, Bryan; Lu, Jiuwei; Weng, Hengyou; Su, Rui; Huang, Huilin; Wang, Yungui; Li, Chenying; Qin, Xi; Mulloy, James C; Zheng, Yi; Diao, Jiajie; Jin, Jie; Li, Chong; Liu, Paul P; He, Chuan; Chen, Yuan; Chen, Jianjun.
Afiliação
  • Jiang X; Department of Cancer Biology, University of Cincinnati, Cincinnati, OH, 45219, USA. xjiang@coh.org.
  • Hu C; Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL, 60637, USA. xjiang@coh.org.
  • Ferchen K; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, 91016, USA. xjiang@coh.org.
  • Nie J; Department of Cancer Biology, University of Cincinnati, Cincinnati, OH, 45219, USA.
  • Cui X; Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL, 60637, USA.
  • Chen CH; Department of Hematology, The First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, 310003, China.
  • Cheng L; Department of Cancer Biology, University of Cincinnati, Cincinnati, OH, 45219, USA.
  • Zuo Z; Department of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, Howard Hughes Medical Institute, University of Chicago, Chicago, IL, 60637, USA.
  • Seibel W; Department of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, Howard Hughes Medical Institute, University of Chicago, Chicago, IL, 60637, USA.
  • He C; Department of Molecular Medicine, Beckman Research Institute of City of Hope, Duarte, CA, 91010, USA.
  • Tang Y; Key Laboratory of Luminescence and Real-time Analytical Chemistry (Ministry of Education), College of Pharmaceutical Sciences, Southwest University, Chongqing, 400715, China.
  • Skibbe JR; Department of Cancer Biology, University of Cincinnati, Cincinnati, OH, 45219, USA.
  • Wunderlich M; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, China.
  • Reinhold WC; Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.
  • Dong L; School of Basic Medical Sciences, Wuhan University, Wuhan, 430071, China.
  • Shen C; Key Laboratory of Luminescence and Real-time Analytical Chemistry (Ministry of Education), College of Pharmaceutical Sciences, Southwest University, Chongqing, 400715, China.
  • Arnovitz S; Department of Cancer Biology, University of Cincinnati, Cincinnati, OH, 45219, USA.
  • Ulrich B; Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.
  • Lu J; Developmental Therapeutics Branch, Center for Cancer Research, NCI, NIH, Bethesda, MD, 20892, USA.
  • Weng H; Department of Cancer Biology, University of Cincinnati, Cincinnati, OH, 45219, USA.
  • Su R; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, 91016, USA.
  • Huang H; Department of Cancer Biology, University of Cincinnati, Cincinnati, OH, 45219, USA.
  • Wang Y; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, 91016, USA.
  • Li C; Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL, 60637, USA.
  • Qin X; Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL, 60637, USA.
  • Mulloy JC; Department of Cancer Biology, University of Cincinnati, Cincinnati, OH, 45219, USA.
  • Zheng Y; Department of Cancer Biology, University of Cincinnati, Cincinnati, OH, 45219, USA.
  • Diao J; Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL, 60637, USA.
  • Jin J; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, 91016, USA.
  • Li C; Department of Cancer Biology, University of Cincinnati, Cincinnati, OH, 45219, USA.
  • Liu PP; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, 91016, USA.
  • He C; Department of Cancer Biology, University of Cincinnati, Cincinnati, OH, 45219, USA.
  • Chen Y; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, 91016, USA.
  • Chen J; Department of Cancer Biology, University of Cincinnati, Cincinnati, OH, 45219, USA.
Nat Commun ; 8(1): 2099, 2017 12 13.
Article em En | MEDLINE | ID: mdl-29235481
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Proteínas Proto-Oncogênicas / Inibidores Enzimáticos / Fator de Transcrição STAT3 / Fator de Transcrição STAT5 / Oxigenases de Função Mista Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Proteínas Proto-Oncogênicas / Inibidores Enzimáticos / Fator de Transcrição STAT3 / Fator de Transcrição STAT5 / Oxigenases de Função Mista Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article