Long-term survival outcomes of triple-receptor negative breast cancer survivors who are disease free at 5 years and relationship with low hormone receptor positivity.
Br J Cancer
; 118(1): 17-23, 2018 01.
Article
em En
| MEDLINE
| ID: mdl-29235566
ABSTRACT
BACKGROUND:
We counsel our triple-negative breast cancer (TNBC) patients that the risk of recurrence is highest in the first 5 years after diagnosis. However, there are limited data with extended follow-up on the frequency, characteristics, and predictors of late events.METHODS:
We queried the MD Anderson Breast Cancer Management System database to identify patients with stage I-III TNBC who were disease free at 5 years from diagnosis. The Kaplan-Meier method was used to estimate yearly recurrence-free interval (RFI), recurrence-free survival (RFS), and distant relapse-free survival (DRFS), as defined by the STEEP criteria. Cox proportional hazards model was used to compute hazard ratios (HRs) and 95% confidence intervals (CIs).RESULTS:
We identified 873 patients who were disease free at least 5 years from diagnosis with median follow-up of 8.3 years. The 10-year RFI was 97%, RFS 91%, and DRFS 92%; the 15-year RFI was 95%, RFS 83%, and DRFS 84%. On a subset of patients with oestrogen receptor and progesterone receptor percentage recorded, low hormone receptor positivity conferred higher risk of late events on multivariable analysis for RFS only (RFI HR=1.98, 95% CI=0.70-5.62, P-value=0.200; RFS HR=1.94, 95% CI=1.05-3.56, P-value=0.034; DRFS HR=1.72, 95% CI=0.92-3.24, P-value=0.091).CONCLUSIONS:
The TNBC survivors who have been disease free for 5 years have a low probability of experiencing recurrence over the subsequent 10 years. Patients with low hormone receptor-positive cancers may have a higher risk of late events as measured by RFS but not by RFI or DRFS.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Receptores de Progesterona
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Receptores de Estrogênio
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Neoplasias de Mama Triplo Negativas
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Recidiva Local de Neoplasia
Tipo de estudo:
Prognostic_studies
Limite:
Adult
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Female
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Humans
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Middle aged
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article