HLA- B*5701 Allele in HIV-infected Indian Children and its Association with Abacavir Hypersensitivity.
Indian Pediatr
; 55(2): 140-141, 2018 02 15.
Article
em En
| MEDLINE
| ID: mdl-29242412
ABSTRACT
OBJECTIVE:
To determine the prevalence of HLA-B*5701 allele in HIV-infected children, and to find its association with Abacavir hypersensitivity.METHODS:
Children (2 to 18 y) already on, or to be initiated on Abacavir were included for PCR sequencing to detect HLA-B*5701. OUTCOME MEASURES WERE proportion with HLA B*5701 allele and hypersensitivity with Abacavir. Abacavir was stopped if patient tested positive for HLA-B*5701 allele.RESULTS:
100 children (median age 11 y) were enrolled; 10 were already on Abacavir. HLA-B*5701 positivity was observed in 11 (11%) children. Two of these 11 children developed hypersensitivity after initiation of Abacavir. Abacavir was thereafter stopped in all who tested HLA-B*5701 positive, irrespective of the development of hypersensitivity reaction.CONCLUSION:
HLA-B*5701 allele was present in 11 (11%) of HIV-infected children, of which two developed Abacavir hypersensitivity. None of the patients without the allele developed hypersensitivity.
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Base de dados:
MEDLINE
Assunto principal:
Didesoxinucleosídeos
/
Antígenos HLA-B
/
Infecções por HIV
/
Fármacos Anti-HIV
/
Hipersensibilidade a Drogas
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Child
/
Child, preschool
/
Female
/
Humans
/
Male
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article