Arid5a stabilizes OX40 mRNA in murine CD4<sup>+</sup> T cells by recognizing a stem-loop structure in its 3'UTR.

Hanieh, Hamza; Masuda, Kazuya; Metwally, Hozaifa; Chalise, Jaya P; Mohamed, Maged; Nyati, Kishan K; Standley, Daron M; Li, Songling; Higa, Mitsuru; Zaman, Mohammad M; Kishimoto, Tadamitsu

Arid5a stabilizes OX40 mRNA in murine CD4⁺ T cells by recognizing a stem-loop structure in its 3'UTR.

Hanieh, Hamza; Masuda, Kazuya; Metwally, Hozaifa; Chalise, Jaya P; Mohamed, Maged; Nyati, Kishan K; Standley, Daron M; Li, Songling; Higa, Mitsuru; Zaman, Mohammad M; Kishimoto, Tadamitsu.

Afiliação

Hanieh H; Physiology Laboratory, Biological Sciences Department, King Faisal University, 31982, Hofuf, Saudi Arabia.
Masuda K; Laboratory of Immune Regulation, World Premier International-Immunology Frontier Research Center, Osaka University, Osaka, 565-0871, Japan.
Metwally H; Laboratory of Immune Regulation, World Premier International-Immunology Frontier Research Center, Osaka University, Osaka, 565-0871, Japan.
Chalise JP; Department of Biochemistry and Biophysics, Howard Hughes Medical Institute, University of Pennsylvania, School of Medicine, Philadelphia, PA, 19104, USA.
Mohamed M; Laboratory of Immune Regulation, World Premier International-Immunology Frontier Research Center, Osaka University, Osaka, 565-0871, Japan.
Nyati KK; Laboratory of Immune Regulation, World Premier International-Immunology Frontier Research Center, Osaka University, Osaka, 565-0871, Japan.
Standley DM; Pharmaceutical Sciences Department, King Faisal University, 31982, Hofuf, Saudi Arabia.
Li S; Pharmacognosy Department, Zagazig University, Zagazig, 44519, Egypt.
Higa M; Laboratory of Immune Regulation, World Premier International-Immunology Frontier Research Center, Osaka University, Osaka, 565-0871, Japan.
Zaman MM; Laboratory of System Immunology, World Premier International-Immunology Frontier Research Center, Osaka University, Osaka, 565-0871, Japan.
Kishimoto T; Laboratory of System Immunology, World Premier International-Immunology Frontier Research Center, Osaka University, Osaka, 565-0871, Japan.

Eur J Immunol ; 48(4): 593-604, 2018 04.

Article em En | MEDLINE | ID: mdl-29244194

Assuntos

Autoimunidade/imunologia; Proteínas de Ligação a DNA/metabolismo; Glicoproteínas de Membrana/genética; Fator de Transcrição STAT3/imunologia; Células Th17/imunologia; Fatores de Transcrição/metabolismo; Fatores de Necrose Tumoral/genética; Transferência Adotiva; Animais; Autoimunidade/genética; Linhagem Celular; Encefalomielite Autoimune Experimental/imunologia; Encefalomielite Autoimune Experimental/patologia; Células HEK293; Humanos; Interleucina-17/biossíntese; Interleucina-6/imunologia; Sequências Repetidas Invertidas/genética; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Ligante OX40; Interferência de RNA; RNA Mensageiro/genética; RNA Interferente Pequeno/genética; Proteínas de Ligação a RNA/metabolismo; Ribonucleases/genética; Fator de Transcrição STAT3/genética; Ubiquitina-Proteína Ligases/genética

Palavras-chave

Arid5a; EAE; IL-17; IL-6; OX40; Th17

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Glicoproteínas de Membrana / Autoimunidade / Fatores de Necrose Tumoral / Proteínas de Ligação a DNA / Fator de Transcrição STAT3 / Células Th17 Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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