Pharmacokinetic profile of PBRM in rodents, a first selective covalent inhibitor of 17ß-HSD1 for breast cancer and endometriosis treatments.

Maltais, René; Trottier, Alexandre; Roy, Jenny; Ayan, Diana; Bertrand, Nicolas; Poirier, Donald

Maltais, René; Trottier, Alexandre; Roy, Jenny; Ayan, Diana; Bertrand, Nicolas; Poirier, Donald.

Afiliação

Maltais R; Laboratory of Medicinal Chemistry, Endocrinology and Nephrology Unit, CHU de Québec - Research Center (CHUL, T4-42), Québec, QC, Canada.
Trottier A; Laboratory of Medicinal Chemistry, Endocrinology and Nephrology Unit, CHU de Québec - Research Center (CHUL, T4-42), Québec, QC, Canada.
Roy J; Laboratory of Medicinal Chemistry, Endocrinology and Nephrology Unit, CHU de Québec - Research Center (CHUL, T4-42), Québec, QC, Canada.
Ayan D; Laboratory of Medicinal Chemistry, Endocrinology and Nephrology Unit, CHU de Québec - Research Center (CHUL, T4-42), Québec, QC, Canada.
Bertrand N; Faculty of Pharmacy, Endocrinology and Nephrology Unit, CHU de Québec - Research Center (CHUL, T4-13), Québec, QC, Canada.
Poirier D; Laboratory of Medicinal Chemistry, Endocrinology and Nephrology Unit, CHU de Québec - Research Center (CHUL, T4-42), Québec, QC, Canada; Department of Molecular Medicine, Faculty of Medicine, Université Laval, Québec, QC, Canada. Electronic address: donald.poirier@crchul.ulaval.ca.

J Steroid Biochem Mol Biol ; 178: 167-176, 2018 04.

Article em En | MEDLINE | ID: mdl-29248731

Assuntos

Benzamidas/química; Neoplasias da Mama/tratamento farmacológico; Endometriose/tratamento farmacológico; Inibidores Enzimáticos/farmacocinética; Estradiol Desidrogenases/antagonistas & inibidores; Animais; Apoptose; Benzamidas/farmacocinética; Benzamidas/farmacologia; Neoplasias da Mama/enzimologia; Neoplasias da Mama/patologia; Proliferação de Células; Endometriose/enzimologia; Endometriose/patologia; Inibidores Enzimáticos/farmacologia; Feminino; Humanos; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Nus; Distribuição Tecidual; Células Tumorais Cultivadas; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

17ß-hydroxysteroid dehydrogenase type 1; Biodistribution; Breast cancer; Endometriosis; Irreversible inhibitor; Pharmacokinetic; Steroid

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Benzamidas / Neoplasias da Mama / Endometriose / Inibidores Enzimáticos / Estradiol Desidrogenases Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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