Multivoxel proton magnetic resonance spectroscopy in facioscapulohumeral muscular dystrophy.
Muscle Nerve
; 57(6): 958-963, 2018 06.
Article
em En
| MEDLINE
| ID: mdl-29266323
ABSTRACT
INTRODUCTION:
Facioscapulohumeral muscular dystrophy (FSHD) is a hereditary disorder that causes progressive muscle wasting. This study evaluates the use of proton magnetic resonance spectroscopy (1 H MRS) as a biomarker of muscle strength and function in FSHD.METHODS:
Thirty-six individuals with FSHD and 15 healthy controls underwent multivoxel 1 H MRS of a cross-section of the mid-thigh. Concentrations of creatine, intramyocellular and extramyocellular lipids, and trimethylamine (TMA)-containing compounds in skeletal muscle were calculated. Metabolite concentrations for individuals with FSHD were compared with those of controls. The relationship between metabolite concentrations and muscle strength was also examined.RESULTS:
The TMA/creatine (Cr) ratio in individuals with FSHD was reduced compared with controls. The TMA/Cr ratio in the hamstrings also showed a moderate linear correlation with muscle strength.DISCUSSION:
1 H MRS offers a potential method of detecting early muscle pathology in FSHD prior to the development of fat infiltration. Muscle Nerve 57 958-963, 2018.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Músculo Esquelético
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Distrofia Muscular Facioescapuloumeral
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Força Muscular
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Espectroscopia de Prótons por Ressonância Magnética
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article