CYP1A1, CYP1B1, GSTM1 and GSTT1 genetic variants and breast cancer risk in Mexican women.
Salud Publica Mex
; 59(5): 540-547, 2017.
Article
em En
| MEDLINE
| ID: mdl-29267651
ABSTRACT
OBJECTIVE:
To evaluate if variants in the genes CYP1A1 (T3801C and A4889G), CYP1B1 (G119T), GSTM1 (indel) and GSTT1 (indel) are associated with breast cancer (BC) among Mexican women. MATERIALS ANDMETHODS:
952 incident cases with histologically confirmed BC were matched by age (± 5 years) and zone of residence with 998 healthy population controls. Genetic variants in genes CYP1A1, CYP1B1, GSTM1 and GSTT1were genotyped by allelic discrimination and multiplex PCR. In a subsample of women, 105 markers for ancestry were determined.RESULTS:
An increased BC risk, independent of other BC risk factors, was observed among carriers of CYP1B1 G119T genotype (T/T vs. G/G OR=1.9; 95%CI 1.4-2.5).CONCLUSION:
Our results support the existence of genetic susceptibility for BC conferred by CYP1B1 G119T variant among Mexican women.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
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Citocromo P-450 CYP1A1
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Polimorfismo de Nucleotídeo Único
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Mutação INDEL
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Citocromo P-450 CYP1B1
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Glutationa Transferase
Tipo de estudo:
Etiology_studies
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Observational_studies
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Risk_factors_studies
Limite:
Adolescent
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Adult
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Aged
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Female
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Humans
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Middle aged
País como assunto:
Africa
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Europa
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Mexico
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article