Reasons to Be Nervous about Flukicide Discovery.
Trends Parasitol
; 34(3): 184-196, 2018 03.
Article
em En
| MEDLINE
| ID: mdl-29269027
ABSTRACT
The majority of anthelmintics dysregulate neuromuscular function, a fact most prominent for drugs against nematode parasites. In contrast to the strong knowledge base for nematode neurobiology, resource and tool deficits have prevented similar advances in flatworm parasites since those driven by bioimaging, immunocytochemistry, and neuropeptide biochemistry 20-30 years ago. However, recent developments are encouraging a renaissance in liver fluke neurobiology that can now support flukicide discovery. Emerging data promote neuromuscular signalling components, and especially G protein-coupled receptors (GPCRs), as next-generation targets. Here, we summarise these data and expose some of the new opportunities to accelerate progress towards GPCR-targeted flukicides for Fasciola hepatica.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pesquisa
/
Fasciolíase
/
Descoberta de Drogas
/
Anti-Helmínticos
Limite:
Animals
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article