Bioactivity evaluation of natural product &#945;-mangostin as a novel xanthone-based lysine-specific demethylase 1 inhibitor to against tumor metastasis.

Han, Chao; Li, Zhongrui; Hou, Jiqin; Wang, Zhen; Xu, Dingqiao; Xue, Guimin; Kong, Lingyi

Bioactivity evaluation of natural product α-mangostin as a novel xanthone-based lysine-specific demethylase 1 inhibitor to against tumor metastasis.

Han, Chao; Li, Zhongrui; Hou, Jiqin; Wang, Zhen; Xu, Dingqiao; Xue, Guimin; Kong, Lingyi.

Afiliação

Han C; State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, China.
Li Z; School of Pharmaceutical Sciences & Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, China.
Hou J; State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, China.
Wang Z; State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, China.
Xu D; State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, China.
Xue G; State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, China.
Kong L; State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, China. Electronic address: cpu_lykong@126.com.

Bioorg Chem ; 76: 415-419, 2018 02.

Article em En | MEDLINE | ID: mdl-29274582

Assuntos

Produtos Biológicos/farmacologia; Movimento Celular/efeitos dos fármacos; Histona Desmetilases/antagonistas & inibidores; Metástase Neoplásica/tratamento farmacológico; Xantonas/farmacologia; Produtos Biológicos/química; Domínio Catalítico; Linhagem Celular Tumoral; Histona Desmetilases/química; Humanos; Simulação de Acoplamento Molecular; Xantonas/química

Palavras-chave

Lysine-specific demethylase 1 inhibitor; Natural product; Tumor metastasis; Xanthone; α-mangostin

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Produtos Biológicos / Movimento Celular / Xantonas / Histona Desmetilases / Metástase Neoplásica Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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