Impact of live attenuated influenza vaccination programme for healthy children in Northern Ireland: A comparison of seven influenza seasons, 2010/11-2016/17.
Vaccine
; 36(4): 521-526, 2018 01 25.
Article
em En
| MEDLINE
| ID: mdl-29275988
ABSTRACT
Seasonal influenza vaccination for healthy children was introduced in Northern Ireland in the 2013/14 flu season, with an initial pilot year involving two specific cohorts, followed by rollout to all children aged 4-11â¯years in subsequent seasons. This study aimed to examine the impact of that programme on the burden of flu in primary care over the study period 2010/11-2016/17. Two routine indicators were used to measure impact - GP in-hour consultations and out-of-hour calls for influenza and influenza-like-illness (ILI). Analysis was conducted overall and stratified by age; rates in children under 14â¯years of age to measure direct impact and rates in individuals 14â¯years and over to measure indirect impact. Seven influenza seasons were included, three pre-programme seasons (2010/11-2012/13 phase 0), one pilot season (2013/14 phase 1), and three post-programme seasons (2014/15-2016/17 phase 2). High uptake of vaccination was observed from the programme introduction, with consistent uptake of over 50% in pre-school age groups and over 75% in primary school age groups. Statistically significant reductions were found in GP in-hours consultations and in out-of-hour calls in phase 2 compared to phase 0, both overall (GP in-hours RR 0.61, 95% CI 0.38-0.98, pâ¯=â¯.040; out-of-hours RR 0.51, 95% CI 0.27-0.97, pâ¯=â¯.041) and in the under 14â¯years group (GP in-hours RR 0.38, 95% CI 0.19-0.75, pâ¯=â¯.006; out-of-hours RR 0.39, 95% CI 0.19-0.83, pâ¯=â¯.014). Our results suggest that there have been reductions in the burden of flu in primary care settings overall and in children aged under 14â¯years in the seasons since the introduction of healthy children influenza vaccination. Further seasons should be added to subsequent analyses to strengthen this evidence.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vacinas contra Influenza
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Vacinas Atenuadas
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Vacinação
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Programas de Imunização
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Influenza Humana
Tipo de estudo:
Incidence_studies
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Prognostic_studies
Limite:
Child
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Child, preschool
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Female
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Humans
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Male
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article