(Radio)fluoroclick Reaction Enabled by a Hydrogen-Bonding Cluster.

Zeng, Xiaojun; Li, Junling; Ng, Chin K; Hammond, Gerald B; Xu, Bo

Zeng, Xiaojun; Li, Junling; Ng, Chin K; Hammond, Gerald B; Xu, Bo.

Afiliação

Zeng X; College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620, China.
Li J; Department of Diagnostic Radiology, University of Louisville, Louisville, KY, 40292, USA.
Ng CK; Department of Diagnostic Radiology, University of Louisville, Louisville, KY, 40292, USA.
Hammond GB; Department of Chemistry, University of Louisville, Louisville, KY, 40292, USA.
Xu B; College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620, China.

Angew Chem Int Ed Engl ; 57(11): 2924-2928, 2018 03 05.

Article em En | MEDLINE | ID: mdl-29276938

ABSTRACT

ABSTRACT

We have developed a widely applicable nucleophilic (radio)fluoroclick reaction of ynamides with readily available and easy-to-handle KF(18 F). The reactions exhibited high functional-group tolerance and needed only an ambient atmosphere. This 18 F addition to C-C unsaturated bonds proceeded with extraordinarily high radiochemical yields.

Palavras-chave

alkali fluorides; fluorination; hydrogen bonds; radiofluorination; ynamides

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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