ALKBH5-dependent m6A demethylation controls splicing and stability of long 3'-UTR mRNAs in male germ cells.

Tang, Chong; Klukovich, Rachel; Peng, Hongying; Wang, Zhuqing; Yu, Tian; Zhang, Ying; Zheng, Huili; Klungland, Arne; Yan, Wei

Tang, Chong; Klukovich, Rachel; Peng, Hongying; Wang, Zhuqing; Yu, Tian; Zhang, Ying; Zheng, Huili; Klungland, Arne; Yan, Wei.

Afiliação

Tang C; Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV 89557.
Klukovich R; Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV 89557.
Peng H; Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV 89557.
Wang Z; Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV 89557.
Yu T; Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV 89557.
Zhang Y; Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV 89557.
Zheng H; Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV 89557.
Klungland A; Department of Microbiology, Oslo University Hospital, Rikshospitalet, 0027 Oslo, Norway.
Yan W; Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, 0317 Oslo, Norway.

Proc Natl Acad Sci U S A ; 115(2): E325-E333, 2018 01 09.

Article em En | MEDLINE | ID: mdl-29279410

Assuntos

Homólogo AlkB 5 da RNA Desmetilase/metabolismo; Glicoproteínas de Membrana/metabolismo; Proteínas do Tecido Nervoso/metabolismo; Splicing de RNA/fisiologia; Espermatócitos/fisiologia; Regiões 3' não Traduzidas; Homólogo AlkB 5 da RNA Desmetilase/genética; Animais; Desmetilação; Células Germinativas; Masculino; Glicoproteínas de Membrana/genética; Camundongos; Camundongos Knockout; Proteínas do Tecido Nervoso/genética; RNA Mensageiro/genética; RNA Mensageiro/metabolismo

Palavras-chave

3'-UTR shortening; RNA methylation; alternative splicing; fertility; mRNA stability

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Espermatócitos / Glicoproteínas de Membrana / Splicing de RNA / Homólogo AlkB 5 da RNA Desmetilase / Proteínas do Tecido Nervoso Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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