Intracerebroventricular administration of Cystatin C ameliorates disease in SOD1-linked amyotrophic lateral sclerosis mice.

Watanabe, Seiji; Komine, Okiru; Endo, Fumito; Wakasugi, Keisuke; Yamanaka, Koji

Watanabe, Seiji; Komine, Okiru; Endo, Fumito; Wakasugi, Keisuke; Yamanaka, Koji.

Afiliação

Watanabe S; Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, Chikusa-ku, Aichi, Japan.
Komine O; Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, Chikusa-ku, Aichi, Japan.
Endo F; Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, Chikusa-ku, Aichi, Japan.
Wakasugi K; Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Komaba, Meguro-ku, Tokyo, Japan.
Yamanaka K; Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, Chikusa-ku, Aichi, Japan.

J Neurochem ; 145(1): 80-89, 2018 04.

Article em En | MEDLINE | ID: mdl-29282717

Assuntos

Esclerose Lateral Amiotrófica; Cistatina C/farmacologia; Neurônios Motores/efeitos dos fármacos; Fármacos Neuroprotetores/farmacologia; Animais; Autofagia/efeitos dos fármacos; Modelos Animais de Doenças; Feminino; Humanos; Masculino; Camundongos; Camundongos Transgênicos; Mutação; Proteínas Recombinantes/farmacologia; Superóxido Dismutase-1/genética

Palavras-chave

AMP-activated kinase (AMPK); Amyotrophic lateral sclerosis (ALS); Cu/Zn superoxide dismutase (SOD1); Cystatin C (CysC)

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fármacos Neuroprotetores / Cistatina C / Esclerose Lateral Amiotrófica / Neurônios Motores Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google