Molecular Mechanisms of UVA-Induced Melanoma.

Pudroma, Xiao; Duoji, Gongsang; Grigalavicius, Mantas; Jie, Duan; Juzeniene, Asta

Pudroma, Xiao; Duoji, Gongsang; Grigalavicius, Mantas; Jie, Duan; Juzeniene, Asta.

Afiliação

Pudroma X; Department of Physics, Tibet University, Lhasa, China.
Duoji G; Department of Mathematics, Tibet University, Lhasa, China.
Grigalavicius M; Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Montebello, 0310 Oslo, Norway.
Jie D; Department of Physics, Tibet University, Lhasa, China.
Juzeniene A; Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Montebello, 0310 Oslo, Norway.

J Environ Pathol Toxicol Oncol ; 36(3): 217-228, 2017.

Article em En | MEDLINE | ID: mdl-29283335

ABSTRACT

ABSTRACT

Cutaneous melanoma is a deadly skin cancer, resulting from malignant transformation of melanocytes. Long-wave ultraviolet radiation (315-400 nm) is able to damage DNA, cause mutations, and induce melanoma. However, the exact mechanisms of UVA-induced cutaneous melanoma remain a matter of debate. In this review, we give a brief characterization of the most important elements in the photobiology of UVA in melanomagenesis.

Assuntos

Melanoma/etiologia; Neoplasias Induzidas por Radiação/etiologia; Neoplasias Cutâneas/etiologia; Raios Ultravioleta; Dano ao DNA; Feminino; Humanos; Masculino; Melaninas/química; Dímeros de Pirimidina/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Cutâneas / Raios Ultravioleta / Melanoma / Neoplasias Induzidas por Radiação Limite: Female / Humans / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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