The Use of Stem Cell Therapy to Reverse Opioid Tolerance.
Clin Pharmacol Ther
; 103(6): 971-974, 2018 06.
Article
em En
| MEDLINE
| ID: mdl-29285750
ABSTRACT
Opioid tolerance (OT) and opioid-induced hyperalgesia (OIH) are major challenges in medicine. Here we report that transplantation of mesenchymal stem cells (MSCs) prevented and reversed OT and OIH in rats and mice. The preventive and therapeutic effects were long-lasting and consistent across different assessment schemes. Both intrathecal and intravenous transplantations were effective and safe. This emerging therapeutic strategy has thus shown promise to impact clinical practice and improve the efficacy and safety of opioid therapy.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transplante de Células-Tronco Mesenquimais
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Tolerância a Medicamentos
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Hiperalgesia
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Analgésicos Opioides
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article