Dermatologic manifestations of solid organ transplantation-associated graft-versus-host disease: A systematic review.
J Am Acad Dermatol
; 78(6): 1097-1101.e1, 2018 Jun.
Article
em En
| MEDLINE
| ID: mdl-29288097
ABSTRACT
BACKGROUND:
Graft-versus-host-disease (GVHD) after solid organ transplantation (SOT) is extremely rare.OBJECTIVE:
To investigate the dermatologic manifestations and clinical outcomes of SOT GVHD.METHODS:
Systematic literature review of SOT GVHD.RESULTS:
After full-text article review, we included 61 articles, representing 115 patients and 126 transplanted organs. The most commonly transplanted organ was the liver (n = 81). Among 115 patients, 101 (87.8%) developed skin involvement. The eruption appeared an average of 48.3 days (range, 3-243 days) posttransplant and was pruritic in 5 of 101 (4.9%) cases. The eruption was described as morbilliform in 2 patients (1.9%), confluent in 6 (5.9%), and desquamative in 4 (3.9%) cases. In many cases, specific dermatologic descriptions were lacking. The mortality rate was 72.2%. Relative time of death was reported in 23 patients who died during the follow-up period. These patients died an average of 99.2 days (range, 22-270 days) posttransplant, or 50.9 days after the appearance of dermatologic symptoms. Frequent causes of death were sepsis and multiorgan failure.LIMITATIONS:
Incomplete descriptions of skin findings and potential publication bias resulting in publication of only the most severe cases.CONCLUSIONS:
GVHD is a potentially fatal condition that can occur after SOT and often presents with a skin rash. We recommend that dermatologists have a low threshold to consider and pursue this diagnosis in the setting of post-SOT skin eruption.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Dermatopatias
/
Transplante de Órgãos
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Doença Enxerto-Hospedeiro
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
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Risk_factors_studies
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Systematic_reviews
Limite:
Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article