Comparison of &#945;ßÎ´ and &#945;ßÎ³ GABA<sub>A</sub> receptors: Allosteric modulation and identification of subunit arrangement by site-selective general anesthetics.

Feng, Hua-Jun; Forman, Stuart A

Comparison of αßÎ´ and αßÎ³ GABA_A receptors: Allosteric modulation and identification of subunit arrangement by site-selective general anesthetics.

Feng, Hua-Jun; Forman, Stuart A.

Afiliação

Feng HJ; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, and Department of Anesthesia, Harvard Medical School, Boston, MA 02114, USA. Electronic address: feng.huajun@mgh.harvard.edu.
Forman SA; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, and Department of Anesthesia, Harvard Medical School, Boston, MA 02114, USA. Electronic address: saforman@mgh.harvard.edu.

Pharmacol Res ; 133: 289-300, 2018 07.

Article em En | MEDLINE | ID: mdl-29294355

Assuntos

Anestésicos Gerais/farmacologia; Subunidades Proteicas/fisiologia; Receptores de GABA-A/fisiologia; Animais; Sítios de Ligação; Humanos; Subunidades Proteicas/química; Receptores de GABA-A/química; Sinapses/fisiologia

Palavras-chave

Allosteric modulation; Alphaxalone; Concatemers; Etomidate; GABA(A) receptors; General anesthetics; Pentobarbital; Propofol; R-5-allyl-1-methyl-5-(m-trifluoromethyl-diazirynylphenyl) barbituric acid (R-mTFD-MPAB); S-1-methyl-5-propyl-5-(m-trifluoromethyl-diazirynylphenyl) barbituric acid (S-mTFD-MPPB); Tetrahydrodeoxycorticosterone (THDOC); αßÎ³; αßÎ´

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores de GABA-A / Anestésicos Gerais / Subunidades Proteicas Tipo de estudo: Diagnostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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