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Activated protein C light chain provides an extended binding surface for its anticoagulant cofactor, protein S.
Fernández, José A; Xu, Xiao; Sinha, Ranjeet K; Mosnier, Laurent O; Sanner, Michel F; Griffin, John H.
Afiliação
  • Fernández JA; Department of Molecular Medicine and.
  • Xu X; Department of Molecular Medicine and.
  • Sinha RK; Department of Molecular Medicine and.
  • Mosnier LO; Department of Molecular Medicine and.
  • Sanner MF; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA.
  • Griffin JH; Department of Molecular Medicine and.
Blood Adv ; 1(18): 1423-1426, 2017 Aug 08.
Article em En | MEDLINE | ID: mdl-29296783
ABSTRACT
Protein S anticoagulant cofactor sensitivity and PAR1 cleavage activity were assayed for 9 recombinant APC mutants.Residues L38, K43, I73, F95, and W115 on one face of the APC light chain define an extended surface containing the protein S binding site.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2017 Tipo de documento: Article