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MLL-AF9 leukemias are sensitive to PARP1 inhibitors combined with cytotoxic drugs.
Maifrede, Silvia; Martinez, Esteban; Nieborowska-Skorska, Margaret; Di Marcantonio, Daniela; Hulse, Michael; Le, Bac Viet; Zhao, Huaqing; Piwocka, Katarzyna; Tempera, Italo; Sykes, Stephen M; Skorski, Tomasz.
Afiliação
  • Maifrede S; Department of Microbiology and Immunology, Temple University Lewis Katz School of Medicine, Philadelphia, PA.
  • Martinez E; Blood Cell Development and Function Program, Research Institute of Fox Chase Cancer Center, Philadelphia, PA.
  • Nieborowska-Skorska M; Department of Microbiology and Immunology, Temple University Lewis Katz School of Medicine, Philadelphia, PA.
  • Di Marcantonio D; Blood Cell Development and Function Program, Research Institute of Fox Chase Cancer Center, Philadelphia, PA.
  • Hulse M; Fels Institute for Cancer Research and Molecular Biology, Temple University Lewis Katz School of Medicine, Philadelphia, PA.
  • Le BV; Department of Microbiology and Immunology, Temple University Lewis Katz School of Medicine, Philadelphia, PA.
  • Zhao H; Laboratory of Cytometry, Nencki Institute of Experimental Biology, Warsaw, Poland; and.
  • Piwocka K; Department of Clinical Sciences, Temple University Lewis Katz School of Medicine, Philadelphia, PA.
  • Tempera I; Laboratory of Cytometry, Nencki Institute of Experimental Biology, Warsaw, Poland; and.
  • Sykes SM; Fels Institute for Cancer Research and Molecular Biology, Temple University Lewis Katz School of Medicine, Philadelphia, PA.
  • Skorski T; Blood Cell Development and Function Program, Research Institute of Fox Chase Cancer Center, Philadelphia, PA.
Blood Adv ; 1(19): 1467-1472, 2017 Aug 22.
Article em En | MEDLINE | ID: mdl-29296788
ABSTRACT
PARP1 is required for the maintenance of MLL-AF9 leukemias.PARP1 inhibitors enhance the therapeutic effect of cytotoxic drugs against MLL-AF9 leukemias.
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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies Idioma: En Ano de publicação: 2017 Tipo de documento: Article