Expression of N-cadherin and ß-catenin in human meningioma in correlation with peritumoral edema.
Int J Neurosci
; 128(9): 805-810, 2018 Sep.
Article
em En
| MEDLINE
| ID: mdl-29297710
ABSTRACT
OBJECTIVE:
To analyze the expression of ß-catenin and N-cadherin in large series of meningioma cases and to investigate their correlation with peritumoral brain edema (PTBE). MATERIALS ANDMETHODS:
Study group consists of 154 patients diagnosed with intracranial meningioma divided into low-grade (G1) and high-grade (G2 or G3) group. PTBE was graded into four groups (0, I, II, III) using Steinhoff classification. The expression of N-cadherin, ß-catenin was analyzed and graded based on the positive ratio of immunoreactivity. The results were analyzed statistically.RESULTS:
104 cases were low-grade and 50 high-grade meningiomas. PTBE was observed in 103(66.8 %) cases 57 grade I, 44 grade II and 2 grade III. Positive N-cadherin expression was found only in the membrane of the neoplastic cells in 50(48.1%) cases of low-grade, and in 34(68%) of high-grade group. In low-grade meningioma, ß-catenin expression was observed within the cytoplasm and nucleus in 54(51.9%) cases. In high-grade meningiomas, ß-catenin expression was observed in 33(66%) tumors only within the nucleus. N-cadherin expression was observed in 36 cases with PTBE grade I, 28 with grade II and 2 with grade III. ß-catenin expression was observed in 40 cases with PTBE grade I, 24 with grade II and 2 with grade III. The results were statistically significant.CONCLUSIONS:
Significant N-cadherin expression especially in high-grade meningioma group was found. ß-catenin expression was the most evident in the nucleus rather than in cytoplasm. The degree of PTBE correlated with the N-cadherin and ß-catenin expression and was the most prominent in high-grade meningioma group.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Edema Encefálico
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Caderinas
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Regulação Neoplásica da Expressão Gênica
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Beta Catenina
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Neoplasias Meníngeas
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Meningioma
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article