Furin promotes dendritic morphogenesis and learning and memory in transgenic mice.
Cell Mol Life Sci
; 75(13): 2473-2488, 2018 07.
Article
em En
| MEDLINE
| ID: mdl-29302702
ABSTRACT
Furin is a proprotein convertase implicated in a variety of pathological processes including neurodegenerative diseases. However, the role of furin in neuronal plasticity and learning and memory remains to be elucidated. Here, we report that in brain-specific furin transgenic (Furin-Tg) mice, the dendritic spine density and proliferation of neural progenitor cells were significantly increased. These mice exhibited enhanced long-term potentiation (LTP) and spatial learning and memory performance, without alterations of miniature excitatory/inhibitory postsynaptic currents. In the cortex and hippocampus of Furin-Tg mice, the ratio of mature brain-derived neurotrophic factor (mBDNF) to pro-BDNF, and the activities of extracellular signal-related kinase (ERK) and cAMP response element-binding protein (CREB) were significantly elevated. We also found that hippocampal knockdown of CREB diminished the facilitation of LTP and cognitive function in Furin-Tg mice. Together, our results demonstrate that furin enhances dendritic morphogenesis and learning and memory in transgenic mice, which may be associated with BDNF-ERK-CREB signaling pathway.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Aprendizagem em Labirinto
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Dendritos
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Furina
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Memória
Limite:
Animals
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article