Fibronectin type III domain containing 5 attenuates NLRP3 inflammasome activation and phenotypic transformation of adventitial fibroblasts in spontaneously hypertensive rats.

Ling, Li; Chen, Dan; Tong, Ying; Zang, Ying-Hao; Ren, Xing-Sheng; Zhou, Hong; Qi, Xiao-Hong; Chen, Qi; Li, Yue-Hua; Kang, Yu-Ming; Zhu, Guo-Qing

Ling, Li; Chen, Dan; Tong, Ying; Zang, Ying-Hao; Ren, Xing-Sheng; Zhou, Hong; Qi, Xiao-Hong; Chen, Qi; Li, Yue-Hua; Kang, Yu-Ming; Zhu, Guo-Qing.

Afiliação

Ling L; Key Laboratory of Cardiovascular Disease and Molecular Intervention, Department of Physiology.
Chen D; Key Laboratory of Cardiovascular Disease and Molecular Intervention, Department of Physiology.
Tong Y; Key Laboratory of Cardiovascular Disease and Molecular Intervention, Department of Physiology.
Zang YH; Key Laboratory of Cardiovascular Disease and Molecular Intervention, Department of Physiology.
Ren XS; Key Laboratory of Cardiovascular Disease and Molecular Intervention, Department of Physiology.
Zhou H; Key Laboratory of Cardiovascular Disease and Molecular Intervention, Department of Physiology.
Qi XH; Department of Pathophysiology, Nanjing Medical University, Nanjing, Jiangsu.
Chen Q; Department of Pathophysiology, Nanjing Medical University, Nanjing, Jiangsu.
Li YH; Department of Pathophysiology, Nanjing Medical University, Nanjing, Jiangsu.
Kang YM; Department of Physiology and Pathophysiology, Cardiovascular Research Center, Xi'an Jiaotong University School of Medicine, Xi'an, China.
Zhu GQ; Key Laboratory of Cardiovascular Disease and Molecular Intervention, Department of Physiology.

J Hypertens ; 36(5): 1104-1114, 2018 05.

Article em En | MEDLINE | ID: mdl-29303830

Assuntos

Fibroblastos/fisiologia; Fibronectinas/metabolismo; Hipertensão/fisiopatologia; Inflamassomos/metabolismo; Proteína 3 que Contém Domínio de Pirina da Família NLR/metabolismo; Túnica Adventícia/patologia; Animais; Aorta/patologia; Pressão Sanguínea; Matriz Extracelular/metabolismo; Fibroblastos/patologia; Fibronectinas/farmacologia; Inflamassomos/efeitos dos fármacos; Masculino; NADPH Oxidase 2/metabolismo; Fenótipo; Ratos; Ratos Endogâmicos SHR; Ratos Endogâmicos WKY; Espécies Reativas de Oxigênio/metabolismo; Remodelação Vascular

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fibronectinas / Inflamassomos / Fibroblastos / Proteína 3 que Contém Domínio de Pirina da Família NLR / Hipertensão Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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