A selective cyclin-dependent kinase 4, 6 dual inhibitor, Ribociclib (LEE011) inhibits cell proliferation and induces apoptosis in aggressive thyroid cancer.

Lee, Hyun Joo; Lee, Woo Kyung; Kang, Chan Woo; Ku, Cheol Ryong; Cho, Yoon Hee; Lee, Eun Jig

Lee, Hyun Joo; Lee, Woo Kyung; Kang, Chan Woo; Ku, Cheol Ryong; Cho, Yoon Hee; Lee, Eun Jig.

Afiliação

Lee HJ; Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.
Lee WK; Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea; Brain Korea 21 PLUS Project for Medical Science, Yonsei University, Seoul, South Korea.
Kang CW; Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.
Ku CR; Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.
Cho YH; Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.
Lee EJ; Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea; Brain Korea 21 PLUS Project for Medical Science, Yonsei University, Seoul, South Korea. Electronic address: EJLEE423@yuhs.ac.

Cancer Lett ; 417: 131-140, 2018 03 28.

Article em En | MEDLINE | ID: mdl-29306020

Assuntos

Aminopiridinas/farmacologia; Apoptose/efeitos dos fármacos; Proliferação de Células/efeitos dos fármacos; Purinas/farmacologia; Neoplasias da Glândula Tireoide/tratamento farmacológico; Ensaios Antitumorais Modelo de Xenoenxerto; Animais; Linhagem Celular Tumoral; Ciclina D/metabolismo; Quinase 4 Dependente de Ciclina/antagonistas & inibidores; Quinase 4 Dependente de Ciclina/metabolismo; Quinase 6 Dependente de Ciclina/antagonistas & inibidores; Quinase 6 Dependente de Ciclina/metabolismo; Pontos de Checagem da Fase G1 do Ciclo Celular/efeitos dos fármacos; Humanos; Masculino; Camundongos Nus; Fosforilação/efeitos dos fármacos; Proteína do Retinoblastoma/metabolismo; Neoplasias da Glândula Tireoide/metabolismo; Neoplasias da Glândula Tireoide/patologia

Palavras-chave

CDK4; CDK6; LEE011; Retinoblastoma protein (RB); Thyroid cancer

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Purinas / Neoplasias da Glândula Tireoide / Apoptose / Ensaios Antitumorais Modelo de Xenoenxerto / Proliferação de Células / Aminopiridinas Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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