Transient activation of PKC results in long-lasting detrimental effects on systolic [Ca<sup>2+</sup>]<sub>i</sub> in cardiomyocytes by altering actin cytoskeletal dynamics and T-tubule integrity.

Guo, Ang; Chen, Rong; Wang, Yihui; Huang, Chun-Kai; Chen, Biyi; Kutschke, William; Hong, Jiang; Song, Long-Sheng

Transient activation of PKC results in long-lasting detrimental effects on systolic [Ca²⁺]_i in cardiomyocytes by altering actin cytoskeletal dynamics and T-tubule integrity.

Guo, Ang; Chen, Rong; Wang, Yihui; Huang, Chun-Kai; Chen, Biyi; Kutschke, William; Hong, Jiang; Song, Long-Sheng.

Afiliação

Guo A; Division of Cardiovascular Medicine, Department of Internal Medicine & Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA; Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China.
Chen R; Division of Cardiovascular Medicine, Department of Internal Medicine & Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA; Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200080, China.
Wang Y; Division of Cardiovascular Medicine, Department of Internal Medicine & Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA; Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200080, China.
Huang CK; Division of Cardiovascular Medicine, Department of Internal Medicine & Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA; Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200080, China.
Chen B; Division of Cardiovascular Medicine, Department of Internal Medicine & Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
Kutschke W; Division of Cardiovascular Medicine, Department of Internal Medicine & Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
Hong J; Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200080, China.
Song LS; Division of Cardiovascular Medicine, Department of Internal Medicine & Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA; Department of Veterans Affairs Medical Center, Iowa City, IA 52242, USA. Electronic address: long-sheng-song@uiow

J Mol Cell Cardiol ; 115: 104-114, 2018 02.

Article em En | MEDLINE | ID: mdl-29307535

Assuntos

Citoesqueleto de Actina/metabolismo; Cálcio/metabolismo; Miócitos Cardíacos/metabolismo; Proteína Quinase C/metabolismo; Sarcolema/metabolismo; Citoesqueleto de Actina/efeitos dos fármacos; Animais; Ativação Enzimática/efeitos dos fármacos; Camundongos Endogâmicos C57BL; Miócitos Cardíacos/efeitos dos fármacos; Canais de Potássio/metabolismo; Pressão; Proteína Quinase C/antagonistas & inibidores; Inibidores de Proteínas Quinases/farmacologia; Sarcolema/efeitos dos fármacos

Palavras-chave

Actin cytoskeleton; Cardiomyocytes; Excitation-contraction coupling; Protein kinase C; T-tubules

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sarcolema / Citoesqueleto de Actina / Proteína Quinase C / Cálcio / Miócitos Cardíacos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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