Enhanced Efflux Pump Activity in Old Candida glabrata Cells.
Antimicrob Agents Chemother
; 62(3)2018 03.
Article
em En
| MEDLINE
| ID: mdl-29311061
ABSTRACT
We investigated the effect of replicative aging on antifungal resistance in Candida glabrata Our studies demonstrate significantly increased transcription of ABC transporters and efflux pump activity in old versus young C. glabrata cells of a fluconazole-sensitive and -resistant strain. In addition, higher tolerance to killing by micafungin and amphotericin B was noted and is associated with higher transcription of glucan synthase gene FKS1 and lower ergosterol content in older cells.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas Fúngicas
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Regulação Fúngica da Expressão Gênica
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Transportadores de Cassetes de Ligação de ATP
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Genes MDR
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Candida glabrata
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Antifúngicos
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article