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Comparative assessment of probiotics and monensin in the prophylaxis of acute ruminal lactic acidosis in sheep.
Reis, Leonardo Frasson; Sousa, Rejane Santos; Oliveira, Francisco Leonardo Costa; Rodrigues, Frederico Augusto Mazzocca Lopes; Araújo, Carolina Akiko Sato Cabral; Meira-Júnior, Enoch Brandão Souza; Barrêto-Júnior, Raimundo Alves; Mori, Clara Satsuki; Minervino, Antonio Humberto Hamad; Ortolani, Enrico Lippi.
Afiliação
  • Reis LF; Department of Clinical Science, Faculty of Veterinary Medicine and Animal Science, University of São Paulo, Av. Prof. Orlando Marques de Paiva, 87, Cidade Universitária, CEP, São Paulo, SP, 05508-270, Brazil.
  • Sousa RS; Department of Clinical Science, Faculty of Veterinary Medicine and Animal Science, University of São Paulo, Av. Prof. Orlando Marques de Paiva, 87, Cidade Universitária, CEP, São Paulo, SP, 05508-270, Brazil.
  • Oliveira FLC; Department of Clinical Science, Faculty of Veterinary Medicine and Animal Science, University of São Paulo, Av. Prof. Orlando Marques de Paiva, 87, Cidade Universitária, CEP, São Paulo, SP, 05508-270, Brazil.
  • Rodrigues FAML; Department of Clinical Science, Faculty of Veterinary Medicine and Animal Science, University of São Paulo, Av. Prof. Orlando Marques de Paiva, 87, Cidade Universitária, CEP, São Paulo, SP, 05508-270, Brazil.
  • Araújo CASC; Department of Clinical Science, Faculty of Veterinary Medicine and Animal Science, University of São Paulo, Av. Prof. Orlando Marques de Paiva, 87, Cidade Universitária, CEP, São Paulo, SP, 05508-270, Brazil.
  • Meira-Júnior EBS; Department of Clinical Science, Faculty of Veterinary Medicine and Animal Science, University of São Paulo, Av. Prof. Orlando Marques de Paiva, 87, Cidade Universitária, CEP, São Paulo, SP, 05508-270, Brazil.
  • Barrêto-Júnior RA; Department of Animal Science, Federal Rural University of the Semiarid Region, Av. Francisco Mota, s/n° - Bairro Pres. Costa e Silva, CEP, Mossoró, RN, 59625-900, Brazil.
  • Mori CS; Department of Clinical Science, Faculty of Veterinary Medicine and Animal Science, University of São Paulo, Av. Prof. Orlando Marques de Paiva, 87, Cidade Universitária, CEP, São Paulo, SP, 05508-270, Brazil.
  • Minervino AHH; Laboratório de Sanidade Animal, Universidade Federal do Oeste do Pará (LARSANA/UFOPA), Av. Vera Paz S/N, Salé, CEP, Santarém, PA, 68000-000, Brazil.
  • Ortolani EL; Department of Clinical Science, Faculty of Veterinary Medicine and Animal Science, University of São Paulo, Av. Prof. Orlando Marques de Paiva, 87, Cidade Universitária, CEP, São Paulo, SP, 05508-270, Brazil. ortolani@usp.br.
BMC Vet Res ; 14(1): 9, 2018 Jan 09.
Article em En | MEDLINE | ID: mdl-29316923
BACKGROUND: Acute ruminal lactic acidosis (ARLA) is a major nutritional and metabolic disorder usually characterized by excessive or non-adapted intake of diets rich in nonstructural carbohydrates. Feed additives that regulate the ruminal environment have been used to prevent ARLA, such as ionophores and, more recently, yeast culture. Thus, we aimed to compare the efficacy of a yeast-based culture (Saccharomyces cerevisiae) with that of monensin sodium in the prevention of ARLA in sheep. Eighteen male, crossbred, rumen-cannulated sheep were randomly distributed into three groups of six animals: control, yeast culture and monensin. Thirty days after the start of supplementation with yeast culture (4 × 109 cfu/animal/day of S. cerevisiae) and monensin (33 mg/kg of total dry matter intake), 15 g/kg BW of sucrose was administered directly into the rumen of the animals to induce ARLA. Samples of blood and ruminal fluid were collected at the following time points: at baseline (T0 h) immediately before the induction of ARLA; 6 h (T6 h); 12 h (T12 h); 18 h (T18 h); 24 h (T24 h); 36 h (T36 h); and 48 h (T48 h) after ARLA induction. RESULTS: Ruminal pH was higher in monensin group at T12 h and in yeast culture group at T36 h when compared to control group. Lower values of L-Lactate were found at yeast culture group at T24 h and T36 h. Monensin showed prophylactic effect by decreasing the rate of ruminal pH decline and occasionally reducing ruminal acidosis, whereas probiotics resulted in less accumulation of lactic acid in the rumen and a lower degree of systemic acidosis. CONCLUSION: The use of yeast culture can be beneficial in the prevention and treatment of ARLA in sheep, because it can effectively reduce the accumulation of lactic acid, and thereby increase ruminal pH and reduce ruminal osmolarity. On the other hand, monensin showed prophylactic effect by decreasing the rate of ruminal pH decline and occasionally reducing ruminal acidosis, however, it did not directly prevent these conditions.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças dos Ovinos / Acidose Láctica / Monensin / Probióticos Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças dos Ovinos / Acidose Láctica / Monensin / Probióticos Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article