N-domain of angiotensin-converting enzyme hydrolyzes human and rat amyloid-ß(1-16) peptides as arginine specific endopeptidase potentially enhancing risk of Alzheimer's disease.

Kugaevskaya, Elena V; Veselovsky, Alexander V; Indeykina, Maria I; Solovyeva, Nina I; Zharkova, Maria S; Popov, Igor A; Nikolaev, Eugene N; Mantsyzov, Alexey B; Makarov, Alexander A; Kozin, Sergey A

Kugaevskaya, Elena V; Veselovsky, Alexander V; Indeykina, Maria I; Solovyeva, Nina I; Zharkova, Maria S; Popov, Igor A; Nikolaev, Eugene N; Mantsyzov, Alexey B; Makarov, Alexander A; Kozin, Sergey A.

Afiliação

Kugaevskaya EV; Institute of Biomedical Chemistry, Moscow, Russia.
Veselovsky AV; Institute of Biomedical Chemistry, Moscow, Russia.
Indeykina MI; Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences, Moscow, Russia.
Solovyeva NI; Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences, Moscow, Russia.
Zharkova MS; Moscow Institute of Physics and Technology, Dolgoprudnyi, Moscow Region, Russia.
Popov IA; Institute of Biomedical Chemistry, Moscow, Russia.
Nikolaev EN; Institute of Biomedical Chemistry, Moscow, Russia.
Mantsyzov AB; Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences, Moscow, Russia.
Makarov AA; Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences, Moscow, Russia.
Kozin SA; Moscow Institute of Physics and Technology, Dolgoprudnyi, Moscow Region, Russia.

Sci Rep ; 8(1): 298, 2018 01 10.

Article em En | MEDLINE | ID: mdl-29321566

Assuntos

Peptídeos beta-Amiloides/metabolismo; Arginina/metabolismo; Peptidil Dipeptidase A/química; Peptidil Dipeptidase A/metabolismo; Domínios e Motivos de Interação entre Proteínas; Serina Endopeptidases/metabolismo; Doença de Alzheimer/etiologia; Doença de Alzheimer/metabolismo; Sequência de Aminoácidos; Peptídeos beta-Amiloides/química; Animais; Humanos; Hidrólise; Espectrometria de Massas; Modelos Moleculares; Conformação Molecular; Proteólise; Ratos; Especificidade por Substrato

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Arginina / Serina Endopeptidases / Peptídeos beta-Amiloides / Peptidil Dipeptidase A / Domínios e Motivos de Interação entre Proteínas Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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