Epidermal growth factor receptor and EGFRvIII in glioblastoma: signaling pathways and targeted therapies.
Oncogene
; 37(12): 1561-1575, 2018 03.
Article
em En
| MEDLINE
| ID: mdl-29321659
ABSTRACT
Amplification of epidermal growth factor receptor (EGFR) and its active mutant EGFRvIII occurs frequently in glioblastoma (GBM). While EGFR and EGFRvIII play critical roles in pathogenesis, targeted therapy with EGFR-tyrosine kinase inhibitors (TKIs) or antibodies has only shown limited efficacy in patients. Here we discuss signaling pathways mediated by EGFR/EGFRvIII, current therapeutics, and novel strategies to target EGFR/EGFRvIII-amplified GBM.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Encefálicas
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Glioblastoma
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Inibidores de Proteínas Quinases
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Terapia de Alvo Molecular
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Receptores ErbB
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article