Ulinastatin attenuates LPS-induced inflammation in mouse macrophage RAW264.7 cells by inhibiting the JNK/NF-&#954;B signaling pathway and activating the PI3K/Akt/Nrf2 pathway.

Li, Si-Tong; Dai, Qi; Zhang, Shu-Xian; Liu, Ya-Jun; Yu, Qiu-Qiong; Tan, Fei; Lu, Shu-Hong; Wang, Quan; Chen, Jian-Wen; Huang, He-Qing; Liu, Pei-Qing; Li, Min

Ulinastatin attenuates LPS-induced inflammation in mouse macrophage RAW264.7 cells by inhibiting the JNK/NF-κB signaling pathway and activating the PI3K/Akt/Nrf2 pathway.

Li, Si-Tong; Dai, Qi; Zhang, Shu-Xian; Liu, Ya-Jun; Yu, Qiu-Qiong; Tan, Fei; Lu, Shu-Hong; Wang, Quan; Chen, Jian-Wen; Huang, He-Qing; Liu, Pei-Qing; Li, Min.

Afiliação

Li ST; School of Pharmaceutical Sciences, National and Local United Engineering Lab of Druggability and New Drugs Evaluation, Sun Yat-Sen University, Guangzhou, 510006, China.
Dai Q; School of Pharmaceutical Sciences, National and Local United Engineering Lab of Druggability and New Drugs Evaluation, Sun Yat-Sen University, Guangzhou, 510006, China.
Zhang SX; School of Pharmaceutical Sciences, National and Local United Engineering Lab of Druggability and New Drugs Evaluation, Sun Yat-Sen University, Guangzhou, 510006, China.
Liu YJ; School of Pharmaceutical Sciences, National and Local United Engineering Lab of Druggability and New Drugs Evaluation, Sun Yat-Sen University, Guangzhou, 510006, China.
Yu QQ; Techpool Bio-Pharma Co, Ltd, Guangzhou, 510520, China.
Tan F; Techpool Bio-Pharma Co, Ltd, Guangzhou, 510520, China.
Lu SH; School of Pharmaceutical Sciences, National and Local United Engineering Lab of Druggability and New Drugs Evaluation, Sun Yat-Sen University, Guangzhou, 510006, China.
Wang Q; School of Pharmaceutical Sciences, National and Local United Engineering Lab of Druggability and New Drugs Evaluation, Sun Yat-Sen University, Guangzhou, 510006, China.
Chen JW; School of Pharmaceutical Sciences, National and Local United Engineering Lab of Druggability and New Drugs Evaluation, Sun Yat-Sen University, Guangzhou, 510006, China.
Huang HQ; School of Pharmaceutical Sciences, National and Local United Engineering Lab of Druggability and New Drugs Evaluation, Sun Yat-Sen University, Guangzhou, 510006, China.
Liu PQ; School of Pharmaceutical Sciences, National and Local United Engineering Lab of Druggability and New Drugs Evaluation, Sun Yat-Sen University, Guangzhou, 510006, China. liupq@mail.sysu.edu.cn.
Li M; School of Pharmaceutical Sciences, National and Local United Engineering Lab of Druggability and New Drugs Evaluation, Sun Yat-Sen University, Guangzhou, 510006, China. limin65@mail.sysu.edu.cn.

Acta Pharmacol Sin ; 39(8): 1294-1304, 2018 Aug.

Article em En | MEDLINE | ID: mdl-29323338

Assuntos

Anti-Inflamatórios não Esteroides/farmacologia; Glicoproteínas/farmacologia; Inflamação/tratamento farmacológico; Proteínas Quinases JNK Ativadas por Mitógeno/antagonistas & inibidores; Inibidores de Serina Proteinase/farmacologia; Transdução de Sinais/efeitos dos fármacos; Animais; Antioxidantes/farmacologia; Citocinas/metabolismo; Proteína 1 Associada a ECH Semelhante a Kelch/metabolismo; Camundongos; Fator 2 Relacionado a NF-E2/metabolismo; Inibidor de NF-kappaB alfa/metabolismo; Fosfatidilinositol 3-Quinase/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Células RAW 264.7; Fator de Transcrição RelA/metabolismo

Palavras-chave

JNK; LPS; NF-κB; Nrf2; PI3K/Akt; RAW264.7 cells; ROS; cytokines; inflammation; ulinastatin

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Glicoproteínas / Transdução de Sinais / Inibidores de Serina Proteinase / Anti-Inflamatórios não Esteroides / Proteínas Quinases JNK Ativadas por Mitógeno / Inflamação Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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