Epstein-Barr Virus (EBV)-induced B-cell Lymphoproliferative Disorder Mimicking the Recurrence of EBV-associated Hemophagocytic Lymphohistiocytosis.
J Pediatr Hematol Oncol
; 41(1): e44-e46, 2019 01.
Article
em En
| MEDLINE
| ID: mdl-29324572
ABSTRACT
We describe the case of a 23-month-old male infant with Epstein-Barr virus (EBV)-associated lymphoproliferative disorder, which mimicked the recurrence of EBV-associated hemophagocytic lymphohistiocytosis. Chemotherapy with dexamethasone, etoposide, and cyclosporine resolved fever, hepatosplenomegaly, and pancytopenia. However, on day 81 of illness, the patient developed similar symptoms. Plasma EBV-DNA levels markedly increased again, but no T-cell clonality was observed. B cells were identified to be infected with EBV. He was successfully treated with rituximab, dexamethasone and etoposide. When recurrence of EBV-associated hemophagocytic lymphohistiocytosis is suspected, performing tests to identify the infected cells will enable accurate understanding of the clinical condition, resulting in proper treatments.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
DNA Viral
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Linfócitos B
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Protocolos de Quimioterapia Combinada Antineoplásica
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Herpesvirus Humano 4
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Infecções por Vírus Epstein-Barr
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Linfo-Histiocitose Hemofagocítica
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Transtornos Linfoproliferativos
Tipo de estudo:
Diagnostic_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Humans
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Infant
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Male
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article